Anti-allergic effect of a chloroform-soluble extract of Cinnamomum cambodianum in bone marrow-derived mast cells

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Title
Anti-allergic effect of a chloroform-soluble extract of Cinnamomum cambodianum in bone marrow-derived mast cells
Author(s)
Hee Sung Chae; P Khiev; Hyeong Kyu Lee; Sei Ryang Oh; Y W Chin
Bibliographic Citation
Immunopharmacology and Immunotoxicology, vol. 34, no. 4, pp. 639-644
Publication Year
2012
Abstract
Cinnamomum cambodianum has been used as a traditional medicine in Cambodia. Its effect on the bone marrow-derived mast cells (BMMCs) mediated allergic response remains unknown. In this study, a chloroform-soluble extract of C. cambodianum was evaluated for its effect on allergicmediators, including prostaglandin D2 (PGD2), leukotriene C4 (LTC4), β-hexosaminidase and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that the chloroform-soluble extractinhibited the production of interleukin-6, PGD2 and LTC4, and the expression of COX-2 in PMA plus calcimycin-stimulated BMMCs, implying a potential benefit of C. cambodianum in the treatment of allergy.
Keyword
Bone marrow-derived mast cellCinnamomum cambodianumDegranulationInterleukin-6Leukotriene C4Prostaglandin D2
ISSN
0892-3973
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.3109/08923973.2011.648267
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
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