Cytotoxic terpenes from the stems of Dipterocarpus obtusifolius collected in Cambodia = 디프테로카퍼스옵투시폴리우스로부터 분리한 세포독성을 갖는 테르펜 화합물

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Title
Cytotoxic terpenes from the stems of Dipterocarpus obtusifolius collected in Cambodia = 디프테로카퍼스옵투시폴리우스로부터 분리한 세포독성을 갖는 테르펜 화합물
Author(s)
P Khiev; Ok-Kyoung Kwon; Hyuk Hwan Song; Sei Ryang OhKyung Seop Ahn; Hyeong Kyu Lee; Y W Chin
Bibliographic Citation
Chemical & Pharmaceutical Bulletin, vol. 60, no. 8, pp. 955-961
Publication Year
2012
Abstract
From the stems of Dipterocarpus obtusifolius, five new triterpenes, 3-oxo-20-hydroxy-30α-methyl,17(29)-α-epoxy-28-norlupane (1), 3-oxo-20-hydroxy-30β-methyl-17(29)α-epoxy-28-norlupane (2), 3,20-dioxo-28,29-norlupan-17α-ol (3), 27-demethyl-20(S)-dammar-23-ene-20- ol-3,25-dione (4), and 3-epi-cecropic acid (5) together with 13 known compounds including diterpene, sesquiterpenes and triterpenes were isolated and characterized. All isolates were tested for their cytotoxicities against a small panel of human cancer cell lines. Of the tested compounds, compounds 4-11 were found to be cytotoxic against one or more human cancer cell lines.
Keyword
CytotoxicityDipterocarpaceaeDipterocarpus obtusifoliusTerpene
ISSN
0009-2363
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/cpb.c12-00012
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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