Humanization by guided selections

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dc.contributor.authorSang Jick Kim-
dc.contributor.authorH J Hong-
dc.date.accessioned2017-04-19T09:33:00Z-
dc.date.available2017-04-19T09:33:00Z-
dc.date.issued2012-
dc.identifier.issn1064-3745-
dc.identifier.uri10.1007/978-1-61779-974-7-14ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10867-
dc.description.abstractGuided selection provides a powerful tool for humanization of the preexisting nonhuman antibodies as exemplified by HUMIRA, the world's first human antibody approved. This chapter describes the sequential guided selection procedure in which mouse VL and VH domains are replaced sequentially with human VL and VH, respectively to derive completely human antibody. The detailed protocols for construction of phage-displayed antibody library, panning, screening, and characterization, are included to achieve successful selection of human antibody with similar characteristics to original mouse antibody.-
dc.publisherSpringer-
dc.titleHumanization by guided selections-
dc.title.alternativeHumanization by guided selections-
dc.typeArticle-
dc.citation.titleMethods in Molecular Biology-
dc.citation.number0-
dc.citation.endPage257-
dc.citation.startPage247-
dc.citation.volume907-
dc.contributor.affiliatedAuthorSang Jick Kim-
dc.contributor.alternativeName김상직-
dc.contributor.alternativeName홍효정-
dc.identifier.bibliographicCitationMethods in Molecular Biology, vol. 907, pp. 247-257-
dc.identifier.doi10.1007/978-1-61779-974-7-14-
dc.subject.keywordAntibody library-
dc.subject.keywordChain shuffling-
dc.subject.keywordGuided selection-
dc.subject.keywordHuman antibody-
dc.subject.keywordPanning-
dc.subject.keywordPhage display-
dc.subject.localAntibody library-
dc.subject.localantibody library-
dc.subject.localChain shuffling-
dc.subject.localchain shuffling-
dc.subject.localGuided selection-
dc.subject.localguided selection-
dc.subject.localHuman antibody-
dc.subject.localhuman antibody-
dc.subject.localpanning-
dc.subject.localPanning-
dc.subject.localPhage display-
dc.subject.localphage display-
dc.description.journalClassN-
Appears in Collections:
Synthetic Biology and Bioengineering Research Institute > Synthetic Biology Research Center > 1. Journal Articles
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