Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells

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dc.contributor.authorHyuk Hwan Song-
dc.contributor.authorHee Sung Chae-
dc.contributor.authorSei Ryang Oh-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorY W Chin-
dc.date.accessioned2017-04-19T09:33:10Z-
dc.date.available2017-04-19T09:33:10Z-
dc.date.issued2012-
dc.identifier.issn0192-415X-
dc.identifier.uri10.1142/S0192415X12500796ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10879-
dc.description.abstractIn this study, the anti-inflammatory and anti-allergic effects of the chloroform-soluble extract of Agaricus blazei in mouse bone marrow-derived mast cells (BMMCs) were investigated. The chloroform-soluble extract inhibited IL-6 production in PMA plus A23187-stimulated BMMCs, and down-regulated the phosphorylation of Akt. In addition, this extract demonstrated inhibition of the degranulation of β-hexosaminidase and the production of IL-6, prostaglandin D 2 and leukotriene C 4 in PMA plus A23187-induced BMMCs. In conclusion, the chloroform-soluble extract of Agaricus blazei exerted anti-inflammatory and anti-allergic activities mediated by influencing IL-6, prostaglandin D 2, leukotriene C 4, and the phosphorylation of Akt.-
dc.publisherWorld Scientific Publ Co Pte Ltd-
dc.titleAnti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells-
dc.title.alternativeAnti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells-
dc.typeArticle-
dc.citation.titleAmerican Journal of Chinese Medicine-
dc.citation.number5-
dc.citation.endPage1084-
dc.citation.startPage1073-
dc.citation.volume40-
dc.contributor.affiliatedAuthorHyuk Hwan Song-
dc.contributor.affiliatedAuthorHee Sung Chae-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName송혁환-
dc.contributor.alternativeName채희성-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName진영원-
dc.identifier.bibliographicCitationAmerican Journal of Chinese Medicine, vol. 40, no. 5, pp. 1073-1084-
dc.identifier.doi10.1142/S0192415X12500796-
dc.subject.keywordAgaricus blazei-
dc.subject.keywordAkt-
dc.subject.keywordBone Marrow Derived Mast Cell-
dc.subject.keywordDegranulation-
dc.subject.keywordInterleukin-6-
dc.subject.keywordLeukotriene C 4-
dc.subject.keywordProstaglandin D 2-
dc.subject.localagaricus blazei-
dc.subject.localAgaricus blazei-
dc.subject.localAKT-
dc.subject.localAkt-
dc.subject.localBone marrow-derived mast cell-
dc.subject.localBone Marrow Derived Mast Cell-
dc.subject.localbone-marrow derived mast cell-
dc.subject.localBone marrow derived mast cell-
dc.subject.localDegranulation-
dc.subject.localIL6-
dc.subject.localinterukin -6-
dc.subject.localInterleukin-6 (IL-6)-
dc.subject.localIL-6-
dc.subject.localIl-6-
dc.subject.localinterleukin-6-
dc.subject.localinterleukin-6 (IL-6)-
dc.subject.localInterleukin-6-
dc.subject.localLeukotriene C4-
dc.subject.localLeukotriene C 4-
dc.subject.localleukotriene C4-
dc.subject.localprostaglandin D2-
dc.subject.localProstaglandin D2-
dc.subject.localProstaglandin D 2-
dc.description.journalClassY-
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Ochang Branch Institute > 1. Journal Articles
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