Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation

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Title
Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation
Author(s)
Won Sam Kim; Dong Oh Kim; Sung Jin Yoon; Mi Jeong Kim; Suk Ran YoonYoung-Jun ParkHaiyoung JungTae-Don Kim; Byoung-Mog Kwon; In Pyo Choi
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 425, no. 2, pp. 340-347
Publication Year
2012
Abstract
Natural killer (NK) cells are a subset of lymphocytes crucial for innate and adaptive immune responses. Here we show a stimulatory effect of cryptotanshinone (CTS) and tanshinone IIA (TS), isolated from Salvia miltiorrhiza Bunge, on the differentiation of NK cells. In the presence of IL-15, tanshinones increased NK cell maturation, NK cell differentiation and the expression of several transcription factors, including Id2, GATA3, T-bet, and Ets-1. Additionally, tanshinones increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, the p38 inhibitor SB203580 blocked the developmental effects of the tanshinones and suppressed Id2, T-bet, and Ets-1 expression during NK cell differentiation. These results suggest that tanshinones
Keyword
CryptotanshinoneDifferentiationId2NK cellsTanshinone IIA
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2012.07.093
Type
Article
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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