CDK2 differentially controls normal cell senescence and cancer cell proliferation upon exposure to reactive oxygen species

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dc.contributor.authorChae Young Hwang-
dc.contributor.authorSeung Min Lee-
dc.contributor.authorSung Sup Park-
dc.contributor.authorKi Sun Kwon-
dc.date.accessioned2017-04-19T09:33:35Z-
dc.date.available2017-04-19T09:33:35Z-
dc.date.issued2012-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2012.07.059ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10916-
dc.description.abstractReactive oxygen species modulate cell fate in a context-dependent manner. Sublethal doses of H 2O 2 decreased the level of proliferating cell nuclear antigen (PCNA) in normal cells (including primary human dermal fibroblasts and IMR-90 cells) without affecting cyclin-dependent kinase 2 (CDK2) activity, leading to cell cycle arrest and subsequent senescence. In contrast, exposure of cancer cells (such as HeLa and MCF7 cells) to H 2O 2 increased CDK2 activity with no accompanying change in the PCNA level, leading to cell proliferation. A CDK2 inhibitor, CVT-313, prevented H 2O 2-induced cancer cell proliferation. These results support the notion that the cyclin/CDK2/p21 Cip1/PCNA complex plays an important role as a regulator of cell fate decisions.-
dc.publisherElsevier-
dc.titleCDK2 differentially controls normal cell senescence and cancer cell proliferation upon exposure to reactive oxygen species-
dc.title.alternativeCDK2 differentially controls normal cell senescence and cancer cell proliferation upon exposure to reactive oxygen species-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number1-
dc.citation.endPage99-
dc.citation.startPage94-
dc.citation.volume425-
dc.contributor.affiliatedAuthorChae Young Hwang-
dc.contributor.affiliatedAuthorSeung Min Lee-
dc.contributor.affiliatedAuthorSung Sup Park-
dc.contributor.affiliatedAuthorKi Sun Kwon-
dc.contributor.alternativeName황채영-
dc.contributor.alternativeName이승민-
dc.contributor.alternativeName박성섭-
dc.contributor.alternativeName권기선-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 425, no. 1, pp. 94-99-
dc.identifier.doi10.1016/j.bbrc.2012.07.059-
dc.subject.keywordCDK2-
dc.subject.keywordH 2O 2-
dc.subject.keywordP21 Cip1-
dc.subject.keywordPCNA-
dc.subject.keywordProliferation-
dc.subject.keywordSenescence-
dc.subject.localCDK2-
dc.subject.localcyclin-dependent kinase 2 (Cdk2)-
dc.subject.localH 2O 2-
dc.subject.localH(2)O(2)-
dc.subject.localH2O2-
dc.subject.localP21 Cip1-
dc.subject.localPCNA-
dc.subject.localProliferation-
dc.subject.localproliferation-
dc.subject.localsenescence-
dc.subject.localSenescence-
dc.description.journalClassY-
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Aging Convergence Research Center > 1. Journal Articles
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