Cycloartane-type triterpene glycosides from the rhizomes of Cimicifuga heracleifolia and their anticomplementary activity

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Title
Cycloartane-type triterpene glycosides from the rhizomes of Cimicifuga heracleifolia and their anticomplementary activity
Author(s)
J H Lee; T D Cuong; S J Kwack; J H Seok; J K Lee; J Y Jeong; M H Woo; J S Choi; Hyeong Kyu Lee; M S Min
Bibliographic Citation
Planta Medica, vol. 78, no. 12, pp. 1391-1394
Publication Year
2012
Abstract
Seven known triterpene glycosides, 23-O-acetylshengmanol 3-O-α-L-arabinopyranoside (1), 23-O-acetylshengmanol 3-O-β-D- xylopyranoside (2), 24-epi-24-O-acetylhydroshengmanol 3-O-β-D- xylopyranoside (3), cimiaceroside B (4), (23R,24S)-cimigenol 3-O-β-D-xylopyranoside (5), (23R,24R)-25-O-acetylcimigenol 3-O-β-D-xylopyranoside (6) and (23R,24S)-25-O-anhydrocimigenol 3-O-β-D-xylopyranoside (7) were isolated from the rhizomes of Cimicifuga heracleifolia. Their chemical structures were determined on the basis of spectroscopic analyses including 2D NMR. All isolates were investigated for their inhibitory effects on the classical pathway of the complement system. Among them, compound 6 showed strong inhibitory activity with an ICvalue of 7.7 M while compound 3 was moderately active with an ICvalue of 195.6 M.
Keyword
anticomplement activityCimicifuga heracleifoliacycloartane glycosideRanunculaceae
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-0032-1314980
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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