Recent trends in development of biosensors for detection of microcystin

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Title
Recent trends in development of biosensors for detection of microcystin
Author(s)
S Singh; A Srivastava; Hee-Mock OhChi-Yong Ahn; G G Choi; R K Asthana
Bibliographic Citation
Toxicon, vol. 60, no. 5, pp. 878-894
Publication Year
2012
Abstract
Increased cyanobacterial blooms, a source of cyanotoxins are linked with climate change and eutrophication in aquatic bodies, a major concern worldwide. Microcystins are potently hepatotoxic, nephrotoxic as well as carcinogenic. Thus microcystins are threat to tourism, agriculture and animal's health. However, there is a still lacuna in the knowledge of regulation of microcystins production. Presence of toxic and non-toxic cyanobacterial strains together and occurrence of various microcystin variants in aquatic bodies compounded the problem. Although several analytical techniques for microcystin detection such as bioassay, ELISA, HPLC and LC-MS etc. have been already prevalent, the development of biosensors offered rapid and accurate detection, high reproducibility and portability. Sequencing of Microcystis spp., opened the new vistas towards the development of biosensor at molecular and genetic level. This review incorporates the current trends in the development of biosensors for microcystin detection in the light of state-of-the-art techniques.
Keyword
Enzyme biosensorImmunosensorMicrocystinNucleic acid biosensor
ISSN
0041-0101
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.toxicon.2012.06.005
Type
Article
Appears in Collections:
Division of Biomaterials Research > Cell Factory Research Center > 1. Journal Articles
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