Amurensin G inhibits angiogenesis and tumor growth of tamoxifen-resistant breast cancer via Pin1 inhibition

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dc.contributor.authorJ A Kim-
dc.contributor.authorM R Kim-
dc.contributor.authorO Kim-
dc.contributor.authorN T T Phuong-
dc.contributor.authorJi Eun Yun-
dc.contributor.authorW K Oh-
dc.contributor.authorK Bae-
dc.contributor.authorK W Kang-
dc.date.accessioned2017-04-19T09:33:39Z-
dc.date.available2017-04-19T09:33:39Z-
dc.date.issued2012-
dc.identifier.issn02786915-
dc.identifier.uri10.1016/j.fct.2012.07.027ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10925-
dc.description.abstractAcquired resistance to tamoxifen (TAM) is a serious therapeutic problem among estrogen-receptor-positive breast cancer patients. We have previously reported that TAM-resistant MCF-7 (TAMR-MCF-7) cells have elevated angiogenic potential via Pin1-dependent vascular endothelial growthfactor (VEGF) production. Vitis amurensis grape consumed as wine and fruit contains several resveratrol-like stilbenes or oligostilbenes. In this study, we screened for the most active compound to inhibit VEGF production from V. amurensis. Among the tested compounds, amurensin G most potently suppressed VEGF production in TAMR-MCF-7 cells. The enhanced VEGF gene transcription in TAMR-MCF-7 cells was suppressed by amurensin G. Molecular analyses using reporter genes with hypoxia response elements and activator protein-1 (AP-1) elements, and western blots revealed that the activities and the nuclear levels of hypoxia inducible factor-1 (HIF-1)α and AP-1 in TAMR-MCF-7 cells were decreased by amurensin G. Moreover, amurensin G concentration-dependently inhibited protein expression and gene transcription of Pin1 in TAMR-MCF-7 cells, which was dependent on E2F1 inhibition. Chick chorioallantoic membrane assays confirmed that amurensin G had significant antiangiogenic and antitumor growth effects in TMAR-MCF-7 cells. These results demonstrate for the first time that amurensin G may have therapeutic potential for TAM-resistant breast cancer through blocking of Pin1-mediated VEGF gene transcription.-
dc.publisherElsevier-
dc.titleAmurensin G inhibits angiogenesis and tumor growth of tamoxifen-resistant breast cancer via Pin1 inhibition-
dc.title.alternativeAmurensin G inhibits angiogenesis and tumor growth of tamoxifen-resistant breast cancer via Pin1 inhibition-
dc.typeArticle-
dc.citation.titleFood and Chemical Toxicology-
dc.citation.number10-
dc.citation.endPage3634-
dc.citation.startPage3625-
dc.citation.volume50-
dc.contributor.alternativeName김정애-
dc.contributor.alternativeName김미라-
dc.contributor.alternativeName김옥-
dc.contributor.alternativeNamePhuong-
dc.contributor.alternativeName윤지은-
dc.contributor.alternativeName오원근-
dc.contributor.alternativeName배기환-
dc.contributor.alternativeName강건욱-
dc.identifier.bibliographicCitationFood and Chemical Toxicology, vol. 50, no. 10, pp. 3625-3634-
dc.identifier.doi10.1016/j.fct.2012.07.027-
dc.subject.keywordAmurensin G-
dc.subject.keywordAngiogenesis-
dc.subject.keywordPin1-
dc.subject.keywordTamoxifen-resistant breast cancer-
dc.subject.keywordVEGF-
dc.subject.keywordVitis amurensis-
dc.subject.localAmurensin G-
dc.subject.localAngiogenesis-
dc.subject.localPin1-
dc.subject.localPIN1-
dc.subject.localTamoxifen-resistant breast cancer-
dc.subject.localVEGF-
dc.subject.localVitis amurensis-
dc.description.journalClassY-
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