Cited 31 time in
- Title
- Over-expression of extracellular superoxide dismutase in mouse synovial tissue attenuates the inflammatory arthritis
- Author(s)
- D H Yu; J K Yi; H S Yuh; S J Park; H J Kim; K B Bae; Y R Ji; N R Kim; S J Park; D H Kim; S H Kim; M O Kim; Jeong Woong Lee; Z Y Ryoo
- Bibliographic Citation
- Experimental and Molecular Medicine, vol. 44, no. 9, pp. 529-535
- Publication Year
- 2012
- Abstract
- Oxidative stress such as reactive oxygen species (ROS) within the inflamed joint have been indicated as being involved as inflammatory mediators in the induction of arthritis. Correlations between extracellular- superoxide dismutase (EC-SOD) and inflammatory arthritis have been shown in several animal models of RA. However, there is a question whether the over-expression of EC-SOD on arthritic joint also could suppress the progression of disease or not. In the present study, the effect on the synovial tissue of experimental arthritis was investigated using EC-SOD over-expressing transgenic mice. The over-expression of EC- SOD in joint tissue was confirmed by RT-PCR and immunohistochemistry. The degree of the inflammation in EC-SOD transgenic mice was suppressed in the collagen-induced arthritis model. In a cytokine assay, the production of pro-inflammatory cytokines such as, IL-1β, TNFα, and matrix metalloproteinases (MMPs) was decreased in fibroblast-like synoviocyte (FLS) but not in peripheral blood. Histological examination also showed repressed cartilage destruction and bone in EC-SOD transgenic mice. In conclusion, these data suggest that the over-expression of EC-SOD in FLS contributes to the activation of FLS and protection from joint destruction by depressing the production of the pro-inflammatory cytokines and MMPs. These results provide EC-SOD transgenic mice with a useful animal model for inflammatory arthritis research.
- Keyword
- Superoxide dismutaseSynovial membraneArthritisExperimentalReactive oxygen speciesRheumatoid arthritis
- ISSN
- I000-0028
- Publisher
- Springer-Nature Pub Group
- DOI
- http://dx.doi.org/10.3858/emm.2012.44.9.060
- Type
- Article
- Appears in Collections:
- Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
- Files in This Item:
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.