A novel therapeutic target, GPR43: where it stands in drug discovery = 신약 타겟 GPR43

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Title
A novel therapeutic target, GPR43: where it stands in drug discovery = 신약 타겟 GPR43
Author(s)
Sunhong Kim; Y M Kim; Young Shin Kwak
Bibliographic Citation
Archives of Pharmacal Research, vol. 35, no. 9, pp. 1505-1509
Publication Year
2012
Abstract
With growing interest in human microbiome for its implication in metabolic disorders, inflammatory diseases, immune disorders and so forth, understanding the biology at the interface of the gut flora and the host becomes very important for identifying novel therapeutic avenues. GPR43 has been deorphanized and the metabolites of microbiome, such as short-chain fatty acids, serve as its natural ligands. There are numerous reports that GPR43 might be a crucial link to the novel therapies for the unmet medical needs and many drug discovery organizations are making their moves in response.
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-012-0900-6
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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