Ingenane-type diterpenes with a modulatory effect on IFN-γ production from the roots of Euphorbia kansui

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dc.contributor.authorP Khiev-
dc.contributor.authorJae Wha Kim-
dc.contributor.authorS J Sung-
dc.contributor.authorHyuk Hwan Song-
dc.contributor.authorDong-Ho Choung-
dc.contributor.authorY W Chin-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorSei Ryang Oh-
dc.date.accessioned2017-04-19T09:34:02Z-
dc.date.available2017-04-19T09:34:02Z-
dc.date.issued2012-
dc.identifier.issn0253-6269-
dc.identifier.uri10.1007/s12272-012-0905-1ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10959-
dc.description.abstractA new ingenane-type diterpene, (3S,5R)5-O-(2,3-dimethylbutanoyl)-13-O- dodecanoyl-20-O-deoxyingenol (1), and six known compounds,3-O-(2,3- dimethylbutanoyl)-13-O-dodecanoyl-20-O-deoxyingenol (2), 20-O-decanoylingenol (3), 20-O-acetylingenol-3-O-(2'E,4'Z) decadienoate (4), kansuiphorin A (5), 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoylingenol (6), and kansuinin F (7) were isolated and evaluated for their effect on IFN-γ production in NK92 cells. Interestingly, subjection to compounds 4 and 6 (10 nM) displayed the most significant response in IFN-γ production, comparable to that produced by the same dose of phorbol 12-myistate 13-acetate (PMA). High doses of compounds 3 (100 nM), 1 (1.25 μM) and 5 (5.0 μM) have also been shown to activate the IFN-γ production.-
dc.publisherPharmaceutical Soc Korea-
dc.titleIngenane-type diterpenes with a modulatory effect on IFN-γ production from the roots of Euphorbia kansui-
dc.title.alternativeIngenane-type diterpenes with a modulatory effect on IFN-γ production from the roots of Euphorbia kansui-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number9-
dc.citation.endPage1558-
dc.citation.startPage1553-
dc.citation.volume35-
dc.contributor.affiliatedAuthorJae Wha Kim-
dc.contributor.affiliatedAuthorHyuk Hwan Song-
dc.contributor.affiliatedAuthorDong-Ho Choung-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.alternativeNameKhiev-
dc.contributor.alternativeName김재화-
dc.contributor.alternativeName성송재-
dc.contributor.alternativeName송혁환-
dc.contributor.alternativeName정동호-
dc.contributor.alternativeName진영원-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName오세량-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 35, no. 9, pp. 1553-1558-
dc.identifier.doi10.1007/s12272-012-0905-1-
dc.subject.keywordEuphorbia kansui-
dc.subject.keywordEuphorbiaceae-
dc.subject.keywordIFN-γ-
dc.subject.keywordIngenane-type diterpenes-
dc.subject.localEuphorbia kansui-
dc.subject.localeuphorbiaceae-
dc.subject.localEuphorbiaceae-
dc.subject.localIFN-γ-
dc.subject.localIfn-γ-
dc.subject.localIFN-gamma-
dc.subject.localIngenane-type diterpenes-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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