Immunosensing using a metal clad leaky waveguide biosensor for clinical diagnosis

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dc.contributor.authorWon Joo Im-
dc.contributor.authorBo Bae Kim-
dc.contributor.authorJu Young Byun-
dc.contributor.authorH M Kim-
dc.contributor.authorM G Kim-
dc.contributor.authorYong Beom Shin-
dc.date.accessioned2017-04-19T09:34:02Z-
dc.date.available2017-04-19T09:34:02Z-
dc.date.issued2012-
dc.identifier.issn0925-4005-
dc.identifier.uri10.1016/j.snb.2012.06.085ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10960-
dc.description.abstractThe optical detection technologies have been used in biosensors for the highly sensitive, real-time and label-free detection of biomolecules. In this report, a metal clad leaky waveguide (MCLW) was used as an immunosensing tools. We optimized the structure of the sensor chip for highly sensitive detection, followed by fabrication of the MCLW sensor chips and construction of a detection system for immunosensing. Titanium and SiO 2 films were deposited onto a BK7 substrate using an E-beam evaporator and the thickness of the films was 9 nm and 347 nm, respectively. The sensing response of the system to the bulk refractive index was calibrated using various concentrations of a glycerol solution. As a result, the MCLW sensor system was able to detect a change of ∼3.8 × 10 -6 RIU in the refractive index of the ambient solution. In addition, immunosensing was achieved using the MCLW sensor for an antigen-antibody reaction in real time. The biotin-labeled antibody of human interleukin 5 (hIL5) was immobilized on the sensor surface containing modified with streptavidin. The hIL5 in a bio-solution was quantitatively analyzed in real time using the MCLW sensor system.-
dc.publisherElsevier-
dc.titleImmunosensing using a metal clad leaky waveguide biosensor for clinical diagnosis-
dc.title.alternativeImmunosensing using a metal clad leaky waveguide biosensor for clinical diagnosis-
dc.typeArticle-
dc.citation.titleSensors and Actuators B-Chemical-
dc.citation.number0-
dc.citation.endPage294-
dc.citation.startPage288-
dc.citation.volume173-
dc.contributor.affiliatedAuthorWon Joo Im-
dc.contributor.affiliatedAuthorBo Bae Kim-
dc.contributor.affiliatedAuthorJu Young Byun-
dc.contributor.affiliatedAuthorYong Beom Shin-
dc.contributor.alternativeName임원주-
dc.contributor.alternativeName김보배-
dc.contributor.alternativeName변주영-
dc.contributor.alternativeName김형민-
dc.contributor.alternativeName김민곤-
dc.contributor.alternativeName신용범-
dc.identifier.bibliographicCitationSensors and Actuators B-Chemical, vol. 173, pp. 288-294-
dc.identifier.doi10.1016/j.snb.2012.06.085-
dc.subject.keywordBiosensor-
dc.subject.keywordImmunosensing-
dc.subject.keywordMetal clad-
dc.subject.keywordOptical waveguide-
dc.subject.localbiosensor-
dc.subject.localBio-sensor-
dc.subject.localBiosensor-
dc.subject.localbiosensors-
dc.subject.localBiosensors-
dc.subject.localimmunosensing-
dc.subject.localImmunosensing-
dc.subject.localMetal clad-
dc.subject.localOptical waveguide-
dc.description.journalClassY-
Appears in Collections:
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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