Randomized controlled trial of Sajabalssuk (Artemisia princeps Pampanini) to treat pre-diabetes

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Title
Randomized controlled trial of Sajabalssuk (Artemisia princeps Pampanini) to treat pre-diabetes
Author(s)
Y Y Cho; N I Baek; H G Chung; Tae Sook Jeong; K T Lee; S M Jeon; H J Kim; R A McGregor; M S Choi
Bibliographic Citation
European Journal of Integrative Medicine, vol. 4, no. 3, pp. e299-e308
Publication Year
2012
Abstract
Introduction: Alternative complementary therapy with medicinal herbs may help restore normal fasting glycemia in pre-diabetes and therefore delay or prevent T2D. The aim of this randomized controlled trial was to assess the efficacy of Sajabalssuk (Artemisia princeps Pampanini) extract to improve fasting glycemia in pre-diabetes. Methodology: Ninety-nine subjects with pre-diabetes (100. mg/dL. <. impaired fasting glucose. <. 125. mg/dL) were randomly assigned into placebo (starch, 2000. mg/day), positive-control (pinitol, 1140. mg/day), and SBE (Sajabalssuk extract 3000. mg/day) groups for 9. weeks. Primary outcomes were fasting blood glucose and HbA1c. Secondary outcomes were insulin resistance, plasma lipid profile and body composition. Dietary intake was also analyzed, and safety was assessed with plasma liver toxicology markers. Results: Nine weeks of SBE treatment significantly lowered fasting blood glucose (-16.51. ±. 2.78%, p<. 0.05) compared placebo or positive-control, effectively restoring normal fasting glycemia. Furthermore, SBE treatment significantly reduced HbA1c (-7.81. ±. 3.39%, p<. 0.05) and insulin resistance (-14.71. ±. 20.37%, p<. 0.05) compared to placebo or positive-control treatment. In addition, SBE treatment improved non-HDL-cholesterol (-11.57. ±. 3.94%, p<. 0.05) and HDL-cholesterol (10.90. ±. 4.35%, p<. 0.05) compared to placebo and positive-control. However, SBE treatment had no effect on other secondary outcomes including atherogenic biomarkers, blood pressure and body composition. Finally, plasma liver toxicology markers were unaltered by SBE treatment. Conclusions: Pre-diabetes treatment with the medicinal herb Sajabalssuk (3000. mg/day) for 9. weeks can improve fasting blood glucose, HbA1c and reduce insulin resistance. SBE treatment appears to have a secondary benefit leading to improved plasma non-HDL and HDL-cholesterol levels. In conclusion, Sajabalssuk extract may provide a useful alternative therapy for management of pre-diabetes.
Keyword
Artemisia princeps PampaniniFasting blood glucoseHbA1cHOMA-IRPinitolRandomized controlled trial
ISSN
1876-3820
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.eujim.2012.01.009
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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