Forced exercise enhances functional recovery after focal cerebral ischemia in spontaneously hypertensive rats = 선천성 고혈압증 흰쥐에서 국소적 뇌경색 이후 강제운동에 의한 기능 회복의 향상

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Title
Forced exercise enhances functional recovery after focal cerebral ischemia in spontaneously hypertensive rats = 선천성 고혈압증 흰쥐에서 국소적 뇌경색 이후 강제운동에 의한 기능 회복의 향상
Author(s)
S Park; J Shin; Y Hong; S Kim; S Lee; K Park; T Lkhagvasuren; Sang Rae Lee; Kyu Tae Chang; Y Hong
Bibliographic Citation
Brain Sciences, vol. 2, no. 4, pp. 483-503
Publication Year
2012
Abstract
Caveolin is the principal protein of caveolae and has been implicated in the pathogenesis of cerebral ischemia. To investigate whether changed expression of caveolins has a pivotal role in focal cerebral ischemia, we induced middle cerebral artery occlusion (MCAo)-reperfusion and examined expression of caveolins, inflammatory activation markers, and mediators of autophagic cell death. We also treated MCAo rats with forced exercise to determine its effects on neurological outcome. Particularly, spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were used to compare the effects of hypertension on focal cerebral ischemia. All MCAo groups showed neurological deficiencies, motor dysfunction, and disruption of balancing ability; however, these pathological changes were more severe in SHR than WKY rats. Expression of caveolins was decreased in MCAo brain tissue, whereas the levels of iNOS and glial fibrillary acidic protein (GFAP) increased. Additionally, LC3-II and beclin-1 levels were elevated in the MCAo groups. Forced exercise attenuated both molecular and behavioral changes in MCAo animals, but SHR rats showed delayed functional recovery and residual molecular changes when compared to WKY rats. These results suggest that forced exercise may be beneficial for promoting functional recovery following cerebral ischemia through caveolin-dependent mechanisms or interactions between caveolins and these signaling molecules in ischemic brain regions.
Keyword
focal cerebral ischemiamiddle cerebral artery occlusioncaveolinsautophagyforced exercisespontaneously hypertensive rat
ISSN
2076-3425
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/brainsci2040483
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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