The role of heterodimeric AP-1 protein comprised of JunD and c-Fos proteins in hematopoiesis

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Title
The role of heterodimeric AP-1 protein comprised of JunD and c-Fos proteins in hematopoiesis
Author(s)
S Y Lee; J Yoon; M H Lee; S K Jung; Dong Joon Kim; A M Bode; J Kim; Z Dong
Bibliographic Citation
Journal of Biological Chemistry, vol. 287, no. 37, pp. 31342-31348
Publication Year
2012
Abstract
Activator protein-1 (AP-1) regulates a wide range of cellular processes including proliferation, differentiation, and apoptosis. As a transcription factor, AP-1 is commonly found as a heterodimer comprised of c-Jun and c-Fos proteins. However, other heterodimers may also be formed. The function of these dimers, specifically the heterodimeric AP-1 comprised of JunD and c-Fos (AP-1 JunD/c-Fos), has not been elucidated. Here, we identified a function of AP-1 JunD/c-Fos in Xenopus hematopoiesis. A gain-of-function study performed by overexpressing junD and c-fos and a loss-of-function study using morpholino junD demonstrate a critical role for AP-1 JunD/c-Fos in hematopoiesis during Xenopus embryogenesis. Additionally, we confirmed that JunD of AP-1 JunD/c-Fos is required for BMP-4-induced hematopoiesis. We also demonstrated that BMP-4 regulated JunD activity at the transcriptional regulation and post-translational modification levels. Collectively, our findings identify AP-1 JunD/c-Fos as a novel hematopoietic transcription factor and the requirement of AP-1 JunD/c-Fos in BMP-4-induced hematopoiesis during Xenopus hematopoiesis.
ISSN
0021-9258
Publisher
Amer Soc Biochemistry Molecular Biology Inc
DOI
http://dx.doi.org/10.1074/jbc.M112.387266
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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