Artemisinin inhibits lipopolysaccharide-induced interferon-beta production in RAW 264.7 cells: implications on signal transducer and activator of transcription-1 signaling and nitric oxide production

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dc.contributor.authorKi Hwan Park-
dc.contributor.authorYeo Dae Yoon-
dc.contributor.authorS B Han-
dc.contributor.authorSoo Jin Oh-
dc.contributor.authorJieun Yun-
dc.contributor.authorChang Woo Lee-
dc.contributor.authorK Lee-
dc.contributor.authorS K Park-
dc.contributor.authorH M Kim-
dc.contributor.authorJong Soon Kang-
dc.date.accessioned2017-04-19T09:34:24Z-
dc.date.available2017-04-19T09:34:24Z-
dc.date.issued2012-
dc.identifier.issn1567-5769-
dc.identifier.uri10.1016/j.intimp.2012.09.012ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10981-
dc.description.abstractArtemisinin is a well-known anti-malarial drug and has been shown to inhibit nitric oxide (NO) production. In this study, we investigated the effect of artemisinin on lipopolysaccharide (LPS)-induced production of IFN-β and characterized the potential relationship between artemisinin-mediated inhibition of IFN-β and NO production. Artemisinin suppressed IFN-β production and mRNA expression in a dose-dependent manner in LPS-stimulated RAW 264.7 cells. LPS-induced phosphorylation of signal transducer and activator of transcription-1 (STAT-1) was also inhibited by artemisinin treatment in RAW 264.7 cells. In addition, artemisinin suppressed LPS-induced production of NO in RAW 264.7 cells. Further study demonstrated that artemisinin-mediated inhibition of NO production and STAT-1 phosphorylation was reversed by addition of exogenous IFN-β. Moreover, artemisinin does not affect IFN-β-induced STAT-1 phosphorylation in RAW 264.7 cells. Collectively, these results suggest that the inhibition of IFN-β production by artemisinin and concomitant attenuation of STAT-1 activation might be involved in artemisinin-mediated inhibition of NO production in macrophages.-
dc.publisherElsevier-
dc.titleArtemisinin inhibits lipopolysaccharide-induced interferon-beta production in RAW 264.7 cells: implications on signal transducer and activator of transcription-1 signaling and nitric oxide production-
dc.title.alternativeArtemisinin inhibits lipopolysaccharide-induced interferon-beta production in RAW 264.7 cells: implications on signal transducer and activator of transcription-1 signaling and nitric oxide production-
dc.typeArticle-
dc.citation.titleInternational Immunopharmacology-
dc.citation.number3-
dc.citation.endPage584-
dc.citation.startPage580-
dc.citation.volume14-
dc.contributor.affiliatedAuthorKi Hwan Park-
dc.contributor.affiliatedAuthorYeo Dae Yoon-
dc.contributor.affiliatedAuthorSoo Jin Oh-
dc.contributor.affiliatedAuthorJieun Yun-
dc.contributor.affiliatedAuthorChang Woo Lee-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeName박기환-
dc.contributor.alternativeName윤여대-
dc.contributor.alternativeName한상배-
dc.contributor.alternativeName오수진-
dc.contributor.alternativeName윤지은-
dc.contributor.alternativeName이창우-
dc.contributor.alternativeName이기호-
dc.contributor.alternativeName박성규-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName강종순-
dc.identifier.bibliographicCitationInternational Immunopharmacology, vol. 14, no. 3, pp. 580-584-
dc.identifier.doi10.1016/j.intimp.2012.09.012-
dc.subject.keywordArtemisinin-
dc.subject.keywordIFN-β-
dc.subject.keywordNitric oxide-
dc.subject.keywordSTAT-1-
dc.subject.localArtemisinin-
dc.subject.localIFN-β-
dc.subject.localNO-
dc.subject.localNO (Nitric oxide)-
dc.subject.localNitric oxid-
dc.subject.localNitric oxide-
dc.subject.localNitric oxide (NO)-
dc.subject.localnitric oxide-
dc.subject.localnitric oxide (NO)-
dc.subject.localnitric oxide.-
dc.subject.localSTAT-1-
dc.subject.localSTAT1-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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