Beta-Lapachon, a modulator of NAD metabolism, prevents health declines in aged mice

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Beta-Lapachon, a modulator of NAD metabolism, prevents health declines in aged mice
J S Lee; A H Park; S H Lee; S H Lee; J H Kim; Suk Jin Yang; Young Il Yeom; T H Kwak; D Lee; S J Lee; Chul Ho Lee; J M Kim; D Kim
Bibliographic Citation
PLoS One, vol. 7, no. 10, pp. e47122-e47122
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NADH-quinone oxidoreductase 1 (NQO1) modulates cellular NAD +/NADH ratio which has been associated with the aging and anti-aging mechanisms of calorie restriction (CR). Here, we demonstrate that the facilitation of NQO1 activity by feeding β-lapachone (βL), an exogenous NQO1 co-substrate, prevented age-dependent decline of motor and cognitive function in aged mice. βL-fed mice did not alter their food-intake or locomotor activity but did increase their energy expenditure as measured by oxygen consumption and heat generation. Mitochondrial structure and numbers were disorganized and decreased in the muscles of control diet group but those defects were less severe in βL-fed aged mice. Furthermore, for a subset of genes associated with energy metabolism, mice fed the βL-diet showed similar changes in gene expression to the CR group (fed 70% of the control diet). These results support the potentiation of NQO1 activity by a βL diet and could be an option for preventing age-related decline of muscle and brain functions.
Public Library of Science
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Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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