Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress

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Title
Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress
Author(s)
Y H Han; Taeho KwonSun-Uk Kim; H L Ha; T H Lee; J M Kim; E K Jo; Bo Yeon Kim; D Y Yoon; Dae Yeul Yu
Bibliographic Citation
BMB Reports, vol. 45, no. 10, pp. 560-564
Publication Year
2012
Abstract
The role of peroxiredoxin (Prx) I as an erythrocyte antioxidant defense in red blood cells (RBCs) is controversial. Here we investigated the function of Prx I by using Prx I-/- and Prx I/II-/- mice. Prx I-/- mice exhibited a normal blood profile. However, Prx I/II-/- mice showed more significantly increased Heinz body formation as compared with Prx II-/- mice. The clearance rate of Heinz body-containing RBCs in Prx I-/- mice decreased significantly through the treatment of aniline hydrochloride (AH) compared with wild-type mice. Prx I deficiency decreased the phagocytic capacity of macrophage in clearing Heinz bodycontaining RBCs. Our data demonstrate that Prx I deficiency did not cause hemolytic anemia, but showed that furtherincreased hemolytic anemia symptoms in Prx II-/- mice by attenuating phagocytic capacity of macrophage in oxidative stress damaged RBCs, suggesting a novel role of Prx I in phagocytosis of macrophage.
Keyword
Heinz bodyHemolytic anemiaMacrophagePeroxiredoxinPhagocytosis
ISSN
1225-8687
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5483/BMBRep.2012.45.10.082
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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