Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress

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dc.contributor.authorY H Han-
dc.contributor.authorTaeho Kwon-
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorH L Ha-
dc.contributor.authorT H Lee-
dc.contributor.authorJ M Kim-
dc.contributor.authorE K Jo-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorD Y Yoon-
dc.contributor.authorDae Yeul Yu-
dc.date.accessioned2017-04-19T09:34:32Z-
dc.date.available2017-04-19T09:34:32Z-
dc.date.issued2012-
dc.identifier.issn1225-8687-
dc.identifier.uri10.5483/BMBRep.2012.45.10.082ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10999-
dc.description.abstractThe role of peroxiredoxin (Prx) I as an erythrocyte antioxidant defense in red blood cells (RBCs) is controversial. Here we investigated the function of Prx I by using Prx I-/- and Prx I/II-/- mice. Prx I-/- mice exhibited a normal blood profile. However, Prx I/II-/- mice showed more significantly increased Heinz body formation as compared with Prx II-/- mice. The clearance rate of Heinz body-containing RBCs in Prx I-/- mice decreased significantly through the treatment of aniline hydrochloride (AH) compared with wild-type mice. Prx I deficiency decreased the phagocytic capacity of macrophage in clearing Heinz bodycontaining RBCs. Our data demonstrate that Prx I deficiency did not cause hemolytic anemia, but showed that furtherincreased hemolytic anemia symptoms in Prx II-/- mice by attenuating phagocytic capacity of macrophage in oxidative stress damaged RBCs, suggesting a novel role of Prx I in phagocytosis of macrophage.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titlePeroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress-
dc.title.alternativePeroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress-
dc.typeArticle-
dc.citation.titleBMB Reports-
dc.citation.number10-
dc.citation.endPage564-
dc.citation.startPage560-
dc.citation.volume45-
dc.contributor.affiliatedAuthorTaeho Kwon-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorDae Yeul Yu-
dc.contributor.alternativeNameHan-
dc.contributor.alternativeName권태호-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeName하혜린-
dc.contributor.alternativeName이태훈-
dc.contributor.alternativeName김진만-
dc.contributor.alternativeName조은경-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName윤도영-
dc.contributor.alternativeName유대열-
dc.identifier.bibliographicCitationBMB Reports, vol. 45, no. 10, pp. 560-564-
dc.identifier.doi10.5483/BMBRep.2012.45.10.082-
dc.subject.keywordHeinz body-
dc.subject.keywordHemolytic anemia-
dc.subject.keywordMacrophage-
dc.subject.keywordPeroxiredoxin-
dc.subject.keywordPhagocytosis-
dc.subject.localHeinz body-
dc.subject.localHemolytic anemia-
dc.subject.localmacrophages-
dc.subject.localmacrophage-
dc.subject.localMacrophages-
dc.subject.localMacrophage-
dc.subject.localPeroxiredoxin-
dc.subject.localperoxiredoxin-
dc.subject.localPeroxiredoxins-
dc.subject.localphagocytosis-
dc.subject.localPhagocytosis-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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