Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation

Abstract

Background: Growth hormone (GH) is involved in hepatic glucose metabolism. Results: GH increased hepatic gluconeogenesis through STAT5 transactivation, which was abolished by the metformin-ATMAMPK-SHP pathway. Conclusion: The metformin-ATM-AMPK-SHP network prevents the increase of hepatic gluconeogenesis by the GH-dependent pathway. Significance: The ATM-AMPK-SHP pathway may provide a novel mechanism for regulating hepatic glucose homeostasis via a GH-dependent pathway.