Overexpression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in colorectal cancer

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dc.contributor.authorK S Kim-
dc.contributor.authorJong-Tae Kim-
dc.contributor.authorSeon-Jin Lee-
dc.contributor.authorM A Kang-
dc.contributor.authorI S Choe-
dc.contributor.authorYun Hee Kang-
dc.contributor.authorSeon-Young Kim-
dc.contributor.authorYoung Il Yeom-
dc.contributor.authorY H Lee-
dc.contributor.authorJ H Kim-
dc.contributor.authorK H Kim-
dc.contributor.authorC N Kim-
dc.contributor.authorJ W Kim-
dc.contributor.authorM S Nam-
dc.contributor.authorHee Gu Lee-
dc.date.accessioned2017-04-19T09:34:54Z-
dc.date.available2017-04-19T09:34:54Z-
dc.date.issued2013-
dc.identifier.issn00098981-
dc.identifier.uri10.1016/j.cca.2012.09.003ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11010-
dc.description.abstractBackground: Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) inhibits anoikis and affects the malignant phenotype of cancer cells. In this study, we analyzed CEACAM6 as a gene that is highly upregulated in colon cancer tissues, and examined the assertion that CEACAM6 might be a suitable candidate tumor marker for the diagnosis of colon cancer. Methods: CEACAM6 gene expression in human colon tissues was performed by tissue microarray and analyzed using RT-PCR (each of normal and tumor tissue, n=. 40) and immunohistochemical and clinicopathological (colon cancer patients, n=. 143) analyses. Results: CEACAM6 transcriptional and translational levels were significantly upregulated in human tumor tissues compared to non-tumor regions, and clinicopathological analysis revealed a significant correlation between CEACAM6 protein expression and Dukes' stage (. p<. 0.001). High expression levels of CEACAM6 were significantly associated with lower overall survival (. p<. 0.001) and shorter recurrence-free survival (. p<. 0.001). We demonstrated that knockdown of CEACAM6 with CEACAM6-specific small interfering RNA in colorectal cancer cells attenuated invasivity (35%); conversely, the overexpression of CEACAM6 increased invasiveness. Conclusions: CEACAM6 is significantly upregulated in colon cancer tissues and is closely associated with poor prognosis, indicating that CEACAM6 might be used as a tumor biomarker and a potential therapeutic target for colon cancer.-
dc.publisherElsevier-
dc.titleOverexpression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in colorectal cancer-
dc.title.alternativeOverexpression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in colorectal cancer-
dc.typeArticle-
dc.citation.titleClinica Chimica Acta-
dc.citation.number1-
dc.citation.endPage19-
dc.citation.startPage12-
dc.citation.volume415-
dc.contributor.affiliatedAuthorJong-Tae Kim-
dc.contributor.affiliatedAuthorSeon-Jin Lee-
dc.contributor.affiliatedAuthorSeon-Young Kim-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.alternativeName김광수-
dc.contributor.alternativeName김종태-
dc.contributor.alternativeName이선진-
dc.contributor.alternativeName강민아-
dc.contributor.alternativeName최인성-
dc.contributor.alternativeName강윤희-
dc.contributor.alternativeName김선영-
dc.contributor.alternativeName염영일-
dc.contributor.alternativeName이영하-
dc.contributor.alternativeName김주헌-
dc.contributor.alternativeName김교현-
dc.contributor.alternativeName김창남-
dc.contributor.alternativeName김종완-
dc.contributor.alternativeName남명수-
dc.contributor.alternativeName이희구-
dc.identifier.bibliographicCitationClinica Chimica Acta, vol. 415, no. 1, pp. 12-19-
dc.identifier.doi10.1016/j.cca.2012.09.003-
dc.subject.keywordCarcinoembryonic antigen-related cell adhesion molecule 6-
dc.subject.keywordColon cancer-
dc.subject.keywordInvasiveness-
dc.subject.keywordMicroarray-
dc.subject.keywordPrognosis-
dc.subject.localCarcinoembryonic antigen-related cell adhesion molecule 6-
dc.subject.localColon cancer-
dc.subject.localInvasiveness-
dc.subject.localMicroarray-
dc.subject.localPrognosis-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Korea Bioinformation Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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