Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene

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Title
Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene
Author(s)
D Chanda; Yong Hoon Kim; D K Kim; M W Lee; S Y Lee; T S Park; S H Koo; Chul Ho Lee; H S Choi
Bibliographic Citation
Journal of Biological Chemistry, vol. 287, no. 45, pp. 38041-38049
Publication Year
2012
Abstract
Background: The role of Cb1r signaling-mediated activation of Crebh in regulating lipid metabolism and insulin signaling is currently unknown. Results: Cb1r signaling regulates Lipin1 gene transcription via Crebh and inhibits insulin receptor signaling. Conclusion: Crebh-mediated activation of Lipin1 by Cb1r deregulates insulin receptor signaling. Significance: Relieving higher hepatic DAG levels by targeting its upstream regulators might be beneficial to restore insulin signaling.
ISSN
0021-9258
Publisher
Amer Soc Biochemistry Molecular Biology Inc
DOI
http://dx.doi.org/10.1074/jbc.M112.377978
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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