A facile synthetic route to diazepinone derivatives via ring closing metathesis and its application for human cytidine deaminase inhibitors

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dc.contributor.authorM Kim-
dc.contributor.authorK Gajulapati-
dc.contributor.authorC Kim-
dc.contributor.authorH Y Jung-
dc.contributor.authorJ Goo-
dc.contributor.authorK Lee-
dc.contributor.authorN Kaur-
dc.contributor.authorHyo Jin Kang-
dc.contributor.authorSang Jeon Chung-
dc.contributor.authorY Choi-
dc.date.accessioned2017-04-19T09:35:26Z-
dc.date.available2017-04-19T09:35:26Z-
dc.date.issued2012-
dc.identifier.issn1359-7345-
dc.identifier.uri10.1039/c2cc35484eko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11026-
dc.description.abstractA variety of diazepinone derivatives were prepared from α-amino acids and amino alcohols by a new synthetic methodology based on ring closing metathesis as a key step. The diazepinones were coupled with ribose derivatives to afford novel diazepinone nucleosides. Among them, (4R)-1-ribosyl-4-methyl-3, 4-dihydro-1H-1,3-diazepin-2(7H)-one (3) showed a potent inhibitory effect (K i = 145.97 ± 4.87 nM) against human cytidine deaminase.-
dc.publisherRoyal Soc Chem-
dc.titleA facile synthetic route to diazepinone derivatives via ring closing metathesis and its application for human cytidine deaminase inhibitors-
dc.title.alternativeA facile synthetic route to diazepinone derivatives via ring closing metathesis and its application for human cytidine deaminase inhibitors-
dc.typeArticle-
dc.citation.titleChemical Communications-
dc.citation.number93-
dc.citation.endPage11445-
dc.citation.startPage11443-
dc.citation.volume48-
dc.contributor.affiliatedAuthorHyo Jin Kang-
dc.contributor.affiliatedAuthorSang Jeon Chung-
dc.contributor.alternativeName김민경-
dc.contributor.alternativeNameGajulapati-
dc.contributor.alternativeName김초롱-
dc.contributor.alternativeName정화영-
dc.contributor.alternativeName구자일-
dc.contributor.alternativeName이경-
dc.contributor.alternativeNameKaur-
dc.contributor.alternativeName강효진-
dc.contributor.alternativeName정상전-
dc.contributor.alternativeName최용석-
dc.identifier.bibliographicCitationChemical Communications, vol. 48, no. 93, pp. 11443-11445-
dc.identifier.doi10.1039/c2cc35484e-
dc.description.journalClassY-
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