DC Field | Value | Language |
---|---|---|
dc.contributor.author | S H Park | - |
dc.contributor.author | J H Song | - |
dc.contributor.author | T Kim | - |
dc.contributor.author | W S Shin | - |
dc.contributor.author | G M Park | - |
dc.contributor.author | S Lee | - |
dc.contributor.author | Y J Kim | - |
dc.contributor.author | P Choi | - |
dc.contributor.author | H Kim | - |
dc.contributor.author | Hui Seong Kim | - |
dc.contributor.author | Dur Han Kwon | - |
dc.contributor.author | H J Choi | - |
dc.contributor.author | J Ham | - |
dc.date.accessioned | 2017-04-19T09:35:34Z | - |
dc.date.available | 2017-04-19T09:35:34Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | 10.3390/md10102222 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11040 | - |
dc.description.abstract | An extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol (1) and five polybromocatechols (2-6) by spectroscopic methods, including 1D and 2D NMR and mass spectrometric analyses. Structurally, all of these compounds, except compound 5, contain one or two 2,3-dibromo-4,5-dihydroxyphenyl moieties. In a biological activity assay, compound 1 was found to possess antiviral activity with a 50% inhibitory concentration (IC 50) of 2.50 μg/mL against HRV2. Compound 3 showed anti-HRV2 activity, with an IC 50 of 7.11 μg/mL, and anti-HRV3 activity, with an IC 50 of 4.69 μg/mL, without demonstrable cytotoxicity at a concentration of 20 μg/mL. Collectively, the results suggest that compounds 1 and 3 are candidates for novel therapeutics against two different groups of human rhinovirus. | - |
dc.publisher | MDPI | - |
dc.title | Anti-human rhinoviral activity of polybromocatechol compounds isolated from the rhodophyta, Neorhodomela aculeate | - |
dc.title.alternative | Anti-human rhinoviral activity of polybromocatechol compounds isolated from the rhodophyta, Neorhodomela aculeate | - |
dc.type | Article | - |
dc.citation.title | Marine Drugs | - |
dc.citation.number | 10 | - |
dc.citation.endPage | 2233 | - |
dc.citation.startPage | 2222 | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Hui Seong Kim | - |
dc.contributor.affiliatedAuthor | Dur Han Kwon | - |
dc.contributor.alternativeName | 박순혜 | - |
dc.contributor.alternativeName | 송재형 | - |
dc.contributor.alternativeName | 김태정 | - |
dc.contributor.alternativeName | 신운섭 | - |
dc.contributor.alternativeName | 박갑만 | - |
dc.contributor.alternativeName | 이석준 | - |
dc.contributor.alternativeName | 김영주 | - |
dc.contributor.alternativeName | 최필주 | - |
dc.contributor.alternativeName | 김희진 | - |
dc.contributor.alternativeName | 김희성 | - |
dc.contributor.alternativeName | 권두한 | - |
dc.contributor.alternativeName | 최화정 | - |
dc.contributor.alternativeName | 함정엽 | - |
dc.identifier.bibliographicCitation | Marine Drugs, vol. 10, no. 10, pp. 2222-2233 | - |
dc.identifier.doi | 10.3390/md10102222 | - |
dc.subject.keyword | Antiviral activity | - |
dc.subject.keyword | Human rhinovirus | - |
dc.subject.keyword | Neorhodomela aculeate | - |
dc.subject.keyword | Polybromocatechol compounds | - |
dc.subject.keyword | Red alga | - |
dc.subject.local | Antiviral activity | - |
dc.subject.local | antiviral activity | - |
dc.subject.local | human rhinovirus | - |
dc.subject.local | Human rhinoviruses | - |
dc.subject.local | Human rhinovirus | - |
dc.subject.local | Neorhodomela aculeate | - |
dc.subject.local | Polybromocatechol compounds | - |
dc.subject.local | Red alga | - |
dc.description.journalClass | Y | - |
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