Anti-human rhinoviral activity of polybromocatechol compounds isolated from the rhodophyta, Neorhodomela aculeate

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dc.contributor.authorS H Park-
dc.contributor.authorJ H Song-
dc.contributor.authorT Kim-
dc.contributor.authorW S Shin-
dc.contributor.authorG M Park-
dc.contributor.authorS Lee-
dc.contributor.authorY J Kim-
dc.contributor.authorP Choi-
dc.contributor.authorH Kim-
dc.contributor.authorHui Seong Kim-
dc.contributor.authorDur Han Kwon-
dc.contributor.authorH J Choi-
dc.contributor.authorJ Ham-
dc.date.accessioned2017-04-19T09:35:34Z-
dc.date.available2017-04-19T09:35:34Z-
dc.date.issued2012-
dc.identifier.issn1660-3397-
dc.identifier.uri10.3390/md10102222ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11040-
dc.description.abstractAn extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol (1) and five polybromocatechols (2-6) by spectroscopic methods, including 1D and 2D NMR and mass spectrometric analyses. Structurally, all of these compounds, except compound 5, contain one or two 2,3-dibromo-4,5-dihydroxyphenyl moieties. In a biological activity assay, compound 1 was found to possess antiviral activity with a 50% inhibitory concentration (IC 50) of 2.50 μg/mL against HRV2. Compound 3 showed anti-HRV2 activity, with an IC 50 of 7.11 μg/mL, and anti-HRV3 activity, with an IC 50 of 4.69 μg/mL, without demonstrable cytotoxicity at a concentration of 20 μg/mL. Collectively, the results suggest that compounds 1 and 3 are candidates for novel therapeutics against two different groups of human rhinovirus.-
dc.publisherMDPI-
dc.titleAnti-human rhinoviral activity of polybromocatechol compounds isolated from the rhodophyta, Neorhodomela aculeate-
dc.title.alternativeAnti-human rhinoviral activity of polybromocatechol compounds isolated from the rhodophyta, Neorhodomela aculeate-
dc.typeArticle-
dc.citation.titleMarine Drugs-
dc.citation.number10-
dc.citation.endPage2233-
dc.citation.startPage2222-
dc.citation.volume10-
dc.contributor.affiliatedAuthorHui Seong Kim-
dc.contributor.affiliatedAuthorDur Han Kwon-
dc.contributor.alternativeName박순혜-
dc.contributor.alternativeName송재형-
dc.contributor.alternativeName김태정-
dc.contributor.alternativeName신운섭-
dc.contributor.alternativeName박갑만-
dc.contributor.alternativeName이석준-
dc.contributor.alternativeName김영주-
dc.contributor.alternativeName최필주-
dc.contributor.alternativeName김희진-
dc.contributor.alternativeName김희성-
dc.contributor.alternativeName권두한-
dc.contributor.alternativeName최화정-
dc.contributor.alternativeName함정엽-
dc.identifier.bibliographicCitationMarine Drugs, vol. 10, no. 10, pp. 2222-2233-
dc.identifier.doi10.3390/md10102222-
dc.subject.keywordAntiviral activity-
dc.subject.keywordHuman rhinovirus-
dc.subject.keywordNeorhodomela aculeate-
dc.subject.keywordPolybromocatechol compounds-
dc.subject.keywordRed alga-
dc.subject.localAntiviral activity-
dc.subject.localantiviral activity-
dc.subject.localhuman rhinovirus-
dc.subject.localHuman rhinoviruses-
dc.subject.localHuman rhinovirus-
dc.subject.localNeorhodomela aculeate-
dc.subject.localPolybromocatechol compounds-
dc.subject.localRed alga-
dc.description.journalClassY-
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