In vitro and in vivo metabolism of verproside in rats

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dc.contributor.authorM G Kim-
dc.contributor.authorD K Hwang-
dc.contributor.authorH U Jeong-
dc.contributor.authorH Y Ji-
dc.contributor.authorSei Ryang Oh-
dc.contributor.authorY Lee-
dc.contributor.authorJ S Yoo-
dc.contributor.authorD H Shin-
dc.contributor.authorH S Lee-
dc.date.accessioned2017-04-19T09:35:35Z-
dc.date.available2017-04-19T09:35:35Z-
dc.date.issued2012-
dc.identifier.issn1420-3049-
dc.identifier.uri10.3390/molecules171011990ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11041-
dc.description.abstractVerproside, a catalpol derivative iridoid glycoside isolated from Pseudolysimachion rotundum var. subintegrum, is a biologically active compound with anti-inflammatory, antinociceptic, antioxidant, and anti-asthmatic properties. Twenty-one metabolites were identified in bile and urine samples obtained after intravenous administration of verproside in rats using liquid chromatography-quadrupole Orbitrap mass spectrometry. Verproside was metabolized by O-methylation, glucuronidation, sulfation, and hydrolysis to verproside glucuronides (M1 and M2), verproside sulfates (M3 and M4), picroside II (M5), M5 glucuronide (M7), M5 sulfate (M9), isovanilloylcatalpol (M6), M6 glucuronide (M8), M6 sulfate (M10), 3,4-dihydroxybenzoic acid (M11), M11 glucuronide (M12), M11 sulfates (M13 and M14), 3-methyoxy-4-hydroxybenzoic acid (M15), M15 glucuronides (M17 and M18), M15 sulfate (M20), 3-hydroxy-4-methoxybenzoic acid (M16), M16 glucuronide (M19), and M16 sulfate (M21). Incubation of verproside with rat hepatocytes resulted in thirteen metabolites (M1-M11, M13, and M14). Verproside sulfate, M4 was a major metabolite in rat hepatocytes. After intravenous administration of verproside, the drug was recovered in bile (0.77% of dose) and urine (4.48% of dose), and O-methylation of verproside to picroside II (M5) and isovanilloylcatalpol (M6) followed by glucuronidation and sulfation was identified as major metabolic pathways compared to glucuronidation and sulfation of verproside in rats.-
dc.publisherMDPI-
dc.titleIn vitro and in vivo metabolism of verproside in rats-
dc.title.alternativeIn vitro and in vivo metabolism of verproside in rats-
dc.typeArticle-
dc.citation.titleMolecules-
dc.citation.number10-
dc.citation.endPage12002-
dc.citation.startPage11990-
dc.citation.volume17-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.alternativeName김민기-
dc.contributor.alternativeName황덕규-
dc.contributor.alternativeName정현욱-
dc.contributor.alternativeName지혜영-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이용남-
dc.contributor.alternativeName유지석-
dc.contributor.alternativeName신대희-
dc.contributor.alternativeName이혜숙-
dc.identifier.bibliographicCitationMolecules, vol. 17, no. 10, pp. 11990-12002-
dc.identifier.doi10.3390/molecules171011990-
dc.subject.keywordLC-HRMS-
dc.subject.keywordRat bile-
dc.subject.keywordRat hepatocytes-
dc.subject.keywordRat urine-
dc.subject.keywordVerproside metabolism-
dc.subject.localLC-HRMS-
dc.subject.localRat bile-
dc.subject.localRat Hepatocytes-
dc.subject.localRat hepatocytes-
dc.subject.localRat urine-
dc.subject.localVerproside metabolism-
dc.description.journalClassY-
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