Spermatotoxic effects of α-chlorohydrin in rats

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dc.contributor.authorS H Kim-
dc.contributor.authorI C Lee-
dc.contributor.authorJ H Lim-
dc.contributor.authorC Moon-
dc.contributor.authorC S Bae-
dc.contributor.authorS H Kim-
dc.contributor.authorD H Shin-
dc.contributor.authorHyoung-Chin Kim-
dc.contributor.authorJ C Kim-
dc.date.accessioned2017-04-19T09:35:35Z-
dc.date.available2017-04-19T09:35:35Z-
dc.date.issued2012-
dc.identifier.issn1738-6055-
dc.identifier.uri10.5625/lar.2012.28.1.11ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11042-
dc.description.abstractThis study was conducted to investigate the potential effects of α-chlorohydrin (ACH) on epididymal function and antioxidant system in male rats. The test chemical was administered to male rats by gavage at doses of 0, 3, 10, and 30 mg/kg/day for 7 days. Twenty-four male rats were randomly assigned to four experimental groups, with six rats in each group. Spermatotoxicity was assessed by measurement of reproductive organ weight, testicular sperm head count, epididymal sperm motility and morphology, histopathologic examination, and oxidative damage analysis in rats. At 30 mg/kg/day, an increase in the incidence of clinical signs, epididymis weight, and gross necropsy findings of the epididymis, a decrease in the sperm motility, and an increased incidence of histopathological changes of the epididymis were observed in a dose-dependent manner. At 10 mg/kg/day, an increased incidence of clinical signs and histopathological changes and decreased sperm motility were observed. In the oxidative damage analysis, an increase in the malondialdehyde concentration and a decrease in the glutathione content and glutathione peroxidase and catalase activities in the epididymal tissue were detected at ≥3 mg/kg/day. The results show that graded doses of ACH elicit depletion of the antioxidant defense system and that the spermatotoxicity of ACH may be due to the induction of oxidative stress.-
dc.publisherSpringer-BMC-
dc.titleSpermatotoxic effects of α-chlorohydrin in rats-
dc.title.alternativeSpermatotoxic effects of α-chlorohydrin in rats-
dc.typeArticle-
dc.citation.titleLaboratory Animal Research-
dc.citation.number1-
dc.citation.endPage16-
dc.citation.startPage11-
dc.citation.volume28-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.alternativeName김성환-
dc.contributor.alternativeName이인철-
dc.contributor.alternativeName임정현-
dc.contributor.alternativeName문창종-
dc.contributor.alternativeName배천식-
dc.contributor.alternativeName김성호-
dc.contributor.alternativeName신동호-
dc.contributor.alternativeName김형진-
dc.contributor.alternativeName김종춘-
dc.identifier.bibliographicCitationLaboratory Animal Research, vol. 28, no. 1, pp. 11-16-
dc.identifier.doi10.5625/lar.2012.28.1.11-
dc.subject.keywordα-Chlorohydrin-
dc.subject.keywordoxidative stress-
dc.subject.keywordreproductive dysfunction-
dc.subject.keywordsperm-
dc.subject.localα-Chlorohydrin-
dc.subject.localα-chlorohydrin-
dc.subject.localOxidative stre-
dc.subject.localOxidative stress-
dc.subject.localOXIDATIVE STRESS-
dc.subject.localOxidative Stress-
dc.subject.localoxidative stress-
dc.subject.localreproductive dysfunction-
dc.subject.localSperm-
dc.subject.localsperm-
dc.description.journalClassN-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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