Protective effects of pine bark extract on hexavalent chromium-induced dermatotoxicity in rats

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dc.contributor.authorIn Chul Lee-
dc.contributor.authorS H Kim-
dc.contributor.authorI S Shin-
dc.contributor.authorC Moon-
dc.contributor.authorS H Park-
dc.contributor.authorS H Kim-
dc.contributor.authorS C Park-
dc.contributor.authorHyoung-Chin Kim-
dc.contributor.authorJ C Kim-
dc.date.accessioned2017-04-19T09:35:36Z-
dc.date.available2017-04-19T09:35:36Z-
dc.date.issued2012-
dc.identifier.issn0951-418X-
dc.identifier.uri10.1002/ptr.4610ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11045-
dc.description.abstractThe present study investigated the protective effects of pine bark extract (PBE) against hexavalent chromium [Cr(VI)]-induced dermatotoxicity in rats. Skin reactions were evaluated by visual inspection, histopathological changes and oxidative stress parameters. Topical application of Cr(VI) produced a significant increase in the incidence and severity of erythema and edema upon visual inspection. Histopathological examination showed moderate to severe necrosis and desquamation in the epidermis and inflammation and hemorrhage in the dermis. In addition, an increased malondialdehyde (MDA) concentration, and decreased glutathione (GSH), catalase, superoxide dismutase, glutathione-S-transferase (GST) and glutathione reductase of the skin were observed in the Cr(VI) group. On the contrary, concomitant administration with PBE significantly improved Cr(VI)-induced dermatotoxicity, evidenced by a decrease in the incidence and severity of skin irritation and histopathological lesions in a dose-dependent manner. Moreover, PBE treatment reduced MDA concentrations and increased catalase and GST activities in skin tissues, indicating that concomitant administration with PBE effectively prevents Cr(VI)-induced oxidative damage in rats. The results indicate that PBE has a protective effect against Cr(VI)-induced dermatotoxicity and is useful as a protective agent against various dermal lesions induced by oxidative stress.-
dc.publisherWiley-
dc.titleProtective effects of pine bark extract on hexavalent chromium-induced dermatotoxicity in rats-
dc.title.alternativeProtective effects of pine bark extract on hexavalent chromium-induced dermatotoxicity in rats-
dc.typeArticle-
dc.citation.titlePhytotherapy Research-
dc.citation.number10-
dc.citation.endPage1540-
dc.citation.startPage1534-
dc.citation.volume26-
dc.contributor.affiliatedAuthorIn Chul Lee-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.alternativeName이인철-
dc.contributor.alternativeName김성환-
dc.contributor.alternativeName신인식-
dc.contributor.alternativeName문창종-
dc.contributor.alternativeName박수현-
dc.contributor.alternativeName김성호-
dc.contributor.alternativeName박성천-
dc.contributor.alternativeName김형진-
dc.contributor.alternativeName김종춘-
dc.identifier.bibliographicCitationPhytotherapy Research, vol. 26, no. 10, pp. 1534-1540-
dc.identifier.doi10.1002/ptr.4610-
dc.subject.keyworddermatotoxicity-
dc.subject.keywordhexavalent chromium-
dc.subject.keywordoxidative stress-
dc.subject.keywordpine bark extract-
dc.subject.keywordprotective effect-
dc.subject.localdermatotoxicity-
dc.subject.localhexavalent chromium-
dc.subject.localOxidative stre-
dc.subject.localOxidative stress-
dc.subject.localOXIDATIVE STRESS-
dc.subject.localOxidative Stress-
dc.subject.localoxidative stress-
dc.subject.localpine bark extract-
dc.subject.localprotective effects-
dc.subject.localProtective effects-
dc.subject.localprotective effect-
dc.subject.localProtective effect-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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