DC Field | Value | Language |
---|---|---|
dc.contributor.author | In Chul Lee | - |
dc.contributor.author | S H Kim | - |
dc.contributor.author | I S Shin | - |
dc.contributor.author | C Moon | - |
dc.contributor.author | S H Park | - |
dc.contributor.author | S H Kim | - |
dc.contributor.author | S C Park | - |
dc.contributor.author | Hyoung-Chin Kim | - |
dc.contributor.author | J C Kim | - |
dc.date.accessioned | 2017-04-19T09:35:36Z | - |
dc.date.available | 2017-04-19T09:35:36Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | 10.1002/ptr.4610 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11045 | - |
dc.description.abstract | The present study investigated the protective effects of pine bark extract (PBE) against hexavalent chromium [Cr(VI)]-induced dermatotoxicity in rats. Skin reactions were evaluated by visual inspection, histopathological changes and oxidative stress parameters. Topical application of Cr(VI) produced a significant increase in the incidence and severity of erythema and edema upon visual inspection. Histopathological examination showed moderate to severe necrosis and desquamation in the epidermis and inflammation and hemorrhage in the dermis. In addition, an increased malondialdehyde (MDA) concentration, and decreased glutathione (GSH), catalase, superoxide dismutase, glutathione-S-transferase (GST) and glutathione reductase of the skin were observed in the Cr(VI) group. On the contrary, concomitant administration with PBE significantly improved Cr(VI)-induced dermatotoxicity, evidenced by a decrease in the incidence and severity of skin irritation and histopathological lesions in a dose-dependent manner. Moreover, PBE treatment reduced MDA concentrations and increased catalase and GST activities in skin tissues, indicating that concomitant administration with PBE effectively prevents Cr(VI)-induced oxidative damage in rats. The results indicate that PBE has a protective effect against Cr(VI)-induced dermatotoxicity and is useful as a protective agent against various dermal lesions induced by oxidative stress. | - |
dc.publisher | Wiley | - |
dc.title | Protective effects of pine bark extract on hexavalent chromium-induced dermatotoxicity in rats | - |
dc.title.alternative | Protective effects of pine bark extract on hexavalent chromium-induced dermatotoxicity in rats | - |
dc.type | Article | - |
dc.citation.title | Phytotherapy Research | - |
dc.citation.number | 10 | - |
dc.citation.endPage | 1540 | - |
dc.citation.startPage | 1534 | - |
dc.citation.volume | 26 | - |
dc.contributor.affiliatedAuthor | In Chul Lee | - |
dc.contributor.affiliatedAuthor | Hyoung-Chin Kim | - |
dc.contributor.alternativeName | 이인철 | - |
dc.contributor.alternativeName | 김성환 | - |
dc.contributor.alternativeName | 신인식 | - |
dc.contributor.alternativeName | 문창종 | - |
dc.contributor.alternativeName | 박수현 | - |
dc.contributor.alternativeName | 김성호 | - |
dc.contributor.alternativeName | 박성천 | - |
dc.contributor.alternativeName | 김형진 | - |
dc.contributor.alternativeName | 김종춘 | - |
dc.identifier.bibliographicCitation | Phytotherapy Research, vol. 26, no. 10, pp. 1534-1540 | - |
dc.identifier.doi | 10.1002/ptr.4610 | - |
dc.subject.keyword | dermatotoxicity | - |
dc.subject.keyword | hexavalent chromium | - |
dc.subject.keyword | oxidative stress | - |
dc.subject.keyword | pine bark extract | - |
dc.subject.keyword | protective effect | - |
dc.subject.local | dermatotoxicity | - |
dc.subject.local | hexavalent chromium | - |
dc.subject.local | Oxidative stre | - |
dc.subject.local | Oxidative stress | - |
dc.subject.local | OXIDATIVE STRESS | - |
dc.subject.local | Oxidative Stress | - |
dc.subject.local | oxidative stress | - |
dc.subject.local | pine bark extract | - |
dc.subject.local | protective effects | - |
dc.subject.local | Protective effects | - |
dc.subject.local | protective effect | - |
dc.subject.local | Protective effect | - |
dc.description.journalClass | Y | - |
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