Importance of sperm capacitation, removal of cumulus matrix, acrosome reaction, and sperm-egg fusion in the process of In vitro fertilization

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Title
Importance of sperm capacitation, removal of cumulus matrix, acrosome reaction, and sperm-egg fusion in the process of In vitro fertilization
Author(s)
K S Kim; K A Hwang; Hyoung-Chin KimKi Hoan Nam; K C Choi
Bibliographic Citation
Journal of Embryo Transfer, vol. 26, no. 4, pp. 287-296
Publication Year
2011
Abstract
Mammalian fertilization is a complex cascade process consisting of sperm migration through the female reproductive tract, physiological changes to sperm such as sperm capacitation and acrosome reaction, and sperm-egg interaction in the oviduct in vivo. On the other hand, in vitro fertilization (IVF) is a process by which egg cells are fertilized by sperm outside the body: in vitro. IVF has been used for a variety of purposes in reproductive biotechnology for human and animals. The discovery of sperm capacitation in 1951 promoted the development of IVF technology. In the initial stage of IVF, sperm capacitation in preincubation medium was shown to be essential to fuse with eggs. Besides, sperms should detour some of the in vivo regulations for IVF. This review introduces a general mammalian fertilization process, including sperm capacitation, removal of cumulus matrix, acrosome reaction, and sperm-egg fusion and focuses on the roles of key biochemical molecules, signal mechanisms, and genes involved during IVF and novel results of sperm-oocyte interaction elucidated in various gene-knockout mice models.
Keyword
in vitro fertilizationreproductionanimal physiology
ISSN
1225-4991
Publisher
South Korea
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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