Evaluation of maternal toxicity in rats exposed to multi-wall carbon nanotubes during pregnancy

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Title
Evaluation of maternal toxicity in rats exposed to multi-wall carbon nanotubes during pregnancy
Author(s)
J H Lim; S H Kim; I C Lee; C Moon; S H Kim; D H Shin; Hyoung-Chin Kim; J C Kim
Bibliographic Citation
Environmental Health and Toxicology, vol. 26, pp. 2011006-2011006
Publication Year
2011
Abstract
Objectives: The present study investigated the potential adverse effects of multi-wall carbon nanotubes (MWCNTs) on pregnant dams and embryonic development following maternal exposure in rats. Methods: MWCNTs were orally administered to pregnant rats from gestational day (GD) 6 through 19 at dose levels of 0, 8, 40, 200, and 1000 mg/kg/day. During the test period, clinical signs, mortality, body weights, food consumption, serum biochemistry, oxidant-antioxidant status, gross findings, organ weights, and Caesarean section findings were examined. Results: All animals survived to the end of the study. A decrease in thymus weight was observed in the highest dose group. However, maternal body weight, food consumption, serum biochemical parameters, and oxidant-antioxidant balance in the kidneys were not affected by treatment with MWCNTs. No treatment-related differences in gestational index, embryo-fetal mortality, or fetal and placental weights were observed between treated and control groups. Conclusions: The results show that 14-day repeated oral dosing of MWCNTs during pregnancy induces minimal maternal toxicity at 1000 mg/kg/day in rats. Under these experimental conditions, the no-observed-adverse-effect level of MWCNTs is considered to be 200 mg/kg/day for dams and 1000 mg/kg/day for embryonic development.
Keyword
Carbon nanotubesPregnancyMaternal toxicityOxidative stressSerum biochemistry
ISSN
2233-6567
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5620/eht.2011.26.e2011006
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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