Analyses of pig genomes provide insight into porcine demography and evolution

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Title
Analyses of pig genomes provide insight into porcine demography and evolution
Author(s)
M A M Groenen; A L Archibald; H Uenishi; C K Tuggle; Y Takeuchi; M F Rothschild; C Rogel-Gaillard; C Park; D Milan; H J Megens; S Li; D M Larkin; H Kim; L A F Frantz; M Caccamo; H Ahn; B L Aken; A Anselmo; C Anthon; L Auvil; Sang-Haeng Choi; Hong-Seog Park; L B Schook
Bibliographic Citation
Nature, vol. 491, no. 7424, pp. 393-398
Publication Year
2012
Abstract
For 10,000a €‰years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ∼1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.
ISSN
0028-0836
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/nature11622
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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