Hybrid polymeric nanomaterials for siRNA delivery and imaging

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Title
Hybrid polymeric nanomaterials for siRNA delivery and imaging
Author(s)
Hyejung Mok; T G Park
Bibliographic Citation
Macromolecular Bioscience, vol. 12, no. 1, pp. 40-48
Publication Year
2012
Abstract
A combined nanomaterials-based approach for simultaneous therapy and molecular imaging has powerful potential for efficient treatment and monitoring the prognosis of incurable diseases such as malignant tumors or degenerative diseases. Recent developments of hybrid polymeric nanomaterials for siRNA delivery and imaging are highlighted. A particular focus is on various conjugation and formulation strategies of how to incorporate siRNA and imaging agents onto the surface of functionally active polymer-coated inorganic nanomaterials such as iron oxide, gold, and quantum-dot nanoparticles for theranostic applications. These multifunctional nanocarriers may allow real-time tracking of siRNA as well as visualization of its therapeutic effects in vitro and in vivo.
Keyword
Cancer therapyDrug deliveryImagingNanomaterialsSiRNA
ISSN
1616-5187
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/mabi.201100169
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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