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- Title
- Regulation of pipernonaline on biological functions of human prostate cancer cells: based on microarray analysis
- Author(s)
- S H Kim; K Y Kim; S N Yu; S K Park; I S Kwak; Moon Soo Rhee; B H Bang; S S Chun; S C Ahn
- Bibliographic Citation
- Journal of Life Science, vol. 22, no. 11, pp. 1552-1557
- Publication Year
- 2012
- Abstract
- It has been reported that pipernonaline isolated from Piper longum Linn. has a wide biochemical and
pharmacological effect, including antitumor activity in prostate cancer PC-3 cells. However, its mechanism
and expression pattern of many genes involved in biological functions are not clearly
understood. To perform the gene expression study in PC-3 cells treated with pipernonaline, we used
cDNA microarray chip composed of 44,000 human cDNA probes. As a result, cell cycle-related genes,
apoptosis-related genes and cell proliferation/growth-related genes have been identified in gene ontology
of DAVID database. These results suggest that pipernonaline has antitumor activity by regulating
the expression pattern of genes involved in biological signaling pathway in prostate cancer PC-3 cells.
Further, additional analysis of these microarray data can be a useful tool to identify the mechanism
and discovery of novel gene in cancer therapy.
- Keyword
- PipernonalinePC-3 cellsmicroarrayexpressionanalysis
- ISSN
- I000-0128
- Publisher
- Korea Soc-Assoc-Inst
- DOI
- http://dx.doi.org/10.5352/JLS.2012.22.11.1552
- Type
- Article
- Appears in Collections:
- Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
- Files in This Item:
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