Mangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma = 망고스틴의 항천식효과

Cited 46 time in scopus
Metadata Downloads
Title
Mangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma = 망고스틴의 항천식효과
Author(s)
Ha Young Jang; Ok-Kyoung KwonSei Ryang Oh; Hyeong Kyu Lee; Kyung Seop Ahn; Y W Chin
Bibliographic Citation
Food and Chemical Toxicology, vol. 50, no. 11, pp. 4042-4050
Publication Year
2012
Abstract
α- and γ-Mangostin, which are the major xanthones purified from a Mangosteen, Garcinia mangostana Linn., exhibit a wide range of anticancer, antioxidant, and anti-inflammatory activities. Here, we assessed their therapeutic effects in a mouse model of ovalbumin (OVA)-induced allergic asthma. Animals were treated with α- and γ-mangostins orally for 3. days at doses of 10 and 30. mg/kg daily, 1. h before the OVA challenge. Administration of α- and γ-mangostins significantly reduced the major pathophysiological features of allergic asthma, including inflammatory cell recruitment into the airway, airway hyperresponsiveness (AHR), and increased levels of Th2 cytokines. In addition, α- and γ-mangostins attenuated the increases in phosphoinositide 3-kinase (PI3K) activity, phosphorylation of Akt, and NF-κB in nuclear protein extracts after OVA challenge. In conclusion, α- and γ-mangostin may have therapeutic potential for the treatment of allergic asthma.
Keyword
α-Mangostinγ-MangostinAsthmaGarcinia mangostana
ISSN
0278-6915
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.fct.2012.08.037
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.