Requirement of CD4 help for induction of CD8 T cell response specific for virally derived h60

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Title
Requirement of CD4 help for induction of CD8 T cell response specific for virally derived h60
Author(s)
S J Ryu; B Kang; Seok Ho Kim; T W Kim; J Chang; E Y Choi
Bibliographic Citation
Immune Network, vol. 12, no. 3, pp. 118-125
Publication Year
2012
Abstract
CD40-CD40L-mediated help from CD4 T cells is essential to induce primary CD8 T cell responses specific to the non-inflammatory cell-based antigen H60. In this study, using H60 as a model antigen, we generated recombinant vaccinia viruses (rVVs) expressing the H60 CD8 epitope and investigated whether CD4 help was required to activate the CD8 T cell response specific to the virally expressed H60. The immune response after infection with rVVs expressing H60 was similar to that after immunization with H60 congenic splenocytes, with a peak frequency of H60-specific CD8 T cells detected in the blood on day 10 post-infection. A CD8 T cell response specific for virally derived H60 was not induced in CD4-depleted mice, but was in CD40-deficient mice. These results provide insights into the characterization of the CD8 T cell response specifically for antigens originating from cellular sources compared to viral sources.
ISSN
I000-0135
Publisher
South Korea
DOI
http://dx.doi.org/10.4110/in.2012.12.3.118
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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