Cited 8 time in
- Title
- Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses
- Author(s)
- R D Michalek; K E Crump; A E Weant; E M Hiltbold; D G Juneau; E Y Moon; Dae Yeul Yu; L B Poole; J M Grayson
- Bibliographic Citation
- Journal of Virology, vol. 86, no. 24, pp. 13629-13641
- Publication Year
- 2012
- Abstract
- Reactive oxygen intermediates (ROI) generated in response to receptor stimulation play an important role in cellular responses. However, the effect of increased H2O2 on an antigen-specific CD8+ T cell response was unknown. Following T cell receptor (TCR) stimulation, the expression and oxidation of peroxiredoxin II (PrdxII), a critical antioxidant enzyme, increased in CD8+ T cells. Deletion of PrdxII increased ROI, S phase entry, division, and death during in vitro division. During primary acute viral and bacterial infection, the number of effector CD8+ T cells in PrdxII-deficient mice was increased, while the number of memory cells were similar to those of the wild-type cells. Adoptive transfer of P14 TCR transgenic cells demonstrated that the increased expansion of effector cells was T cell autonomous. After rechallenge, effector CD8+ T cells in mutant animals were more skewed to memory phenotype than cells from wild-type mice, resulting in a larger secondary memory CD8+ T cell pool. During chronic viral infection, increased antigen-specific CD8+ T cells accumulated in the spleens of PrdxII mutant mice, causing mortality. These results demonstrate that PrdxII controls effector CD8+ T cell expansion, secondary memory generation, and immunopathology.
- ISSN
- 0022-538X
- Publisher
- Amer Soc Microb
- DOI
- http://dx.doi.org/10.1128/JVI.01559-12
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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