CRP detection from serum for chip-based point-of-care testing system

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dc.contributor.authorC H Kim-
dc.contributor.authorJ H Ahn-
dc.contributor.authorJ Y Kim-
dc.contributor.authorJ M Choi-
dc.contributor.authorK C Lim-
dc.contributor.authorT J Park-
dc.contributor.authorN S Heo-
dc.contributor.authorHee Gu Lee-
dc.contributor.authorJ W Kim-
dc.contributor.authorY K Choi-
dc.date.accessioned2017-04-19T09:35:58Z-
dc.date.available2017-04-19T09:35:58Z-
dc.date.issued2013-
dc.identifier.issn0956-5663-
dc.identifier.uri10.1016/j.bios.2012.08.047ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11109-
dc.description.abstractMost of point-of-care testing (POCT) to improve facilitates in diagnosis, treatment, and monitoring of patients. POCT technique has still remained a quantitatively and accurately detective effect. In this article, we demonstrated that real human C-reactive protein (CRP) in serum was detected for a chip-based point-of-care testing application based on a nanogap-embedded field effect transistor (FET), and the results were compared with those obtained via the enzyme-linked immunosorbent assay (ELISA) method. The limit of detection (LOD), determined from the standard curve, was 0.1. ng/ml, which is comparable to that of commercialized ELISAs. We evaluated that an improved detection range (0.1. ng/ml to 100. ng/ml) was achieved by comparing with commercialized ELISA. Control experiments to determine selectivity and to discern false-positive/false-negative rates were also performed. This report is the first description of the detection of CRP in human serum using a silicon-based biosensor.-
dc.publisherElsevier-
dc.titleCRP detection from serum for chip-based point-of-care testing system-
dc.title.alternativeCRP detection from serum for chip-based point-of-care testing system-
dc.typeArticle-
dc.citation.titleBiosensors & Bioelectronics-
dc.citation.number1-
dc.citation.endPage327-
dc.citation.startPage322-
dc.citation.volume41-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.alternativeName김창훈-
dc.contributor.alternativeName안재혁-
dc.contributor.alternativeName김지연-
dc.contributor.alternativeName최지민-
dc.contributor.alternativeName임경춘-
dc.contributor.alternativeName박태정-
dc.contributor.alternativeName허남수-
dc.contributor.alternativeName이희구-
dc.contributor.alternativeName김종완-
dc.contributor.alternativeName최양규-
dc.identifier.bibliographicCitationBiosensors & Bioelectronics, vol. 41, no. 1, pp. 322-327-
dc.identifier.doi10.1016/j.bios.2012.08.047-
dc.subject.keywordC-reactive protein-
dc.subject.keywordCRP-
dc.subject.keywordFET-based biosensor-
dc.subject.keywordNanogap-embedded FET-
dc.subject.keywordPoint-of-care testing (POCT)-
dc.subject.localC-reactive protein-
dc.subject.localC-reactive protein (CRP)-
dc.subject.localCRP-
dc.subject.localFET-based biosensor-
dc.subject.localNanogap-embedded FET-
dc.subject.localPoint-of-care testing (POCT)-
dc.subject.localpoint of care testing-
dc.subject.localPoint-of-care testing-
dc.subject.localpoint-of-care-testing-
dc.subject.localPoint-of-care test (POCT)-
dc.subject.localPOCT-
dc.subject.localPoCT-
dc.subject.localPoint of care testing-
dc.subject.localPoint-of-care test-
dc.subject.localPoint of Care Testing-
dc.subject.localpoint-of-care testing (POCT)-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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