Tumor-associated autoantibodies as diagnostic and prognostic biomarkers

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Title
Tumor-associated autoantibodies as diagnostic and prognostic biomarkers
Author(s)
Chang Gyu Heo; Y Y Bahk; Eun Wie Cho
Bibliographic Citation
BMB Reports, vol. 45, no. 12, pp. 677-685
Publication Year
2012
Abstract
In the process of tumorigenesis, normal cells are remodeled to cancer cells and protein expression patterns are changed to those of tumor cells. A newly formed tumor microenvironment elicits the immune system and, as a result, a humoral immune response takes place. Although the tumor antigens areundetectable in sera at the early stage of tumorigenesis, the nature of an antibody amplification response to antigens makes tumor-associated autoantibodies as promising early biomarkers in cancer diagnosis. Moreover, the recent development of proteomic techniques that make neo-epitopes of tumor-associated autoantigens discovered concomitantly has opened a new area of 'immuno-proteomics',which presents tumor-associated autoantibody signatures and confers information to redefine the process of tumorigenesis. In this article, the strategies recently used to identify and validate serumautoantibodies are outlined and tumor-associated antigens suggested until now as diagnostic/prognostic biomarkers in various tumor types are reviewed. Also, the meaning of autoantibody signatures and their clinical utility in personalized medicine are discussed.
Keyword
BiomarkerDiagnosticPrognosticTumor-associated autoantibodyTumor-associated autoantigen
ISSN
1225-8687
Publisher
South Korea
DOI
http://dx.doi.org/10.5483/BMBRep.2012.45.12.236
Type
Article
Appears in Collections:
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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