Effusanin C inhibits inflammatory responses via blocking NF-kB and MAPK signaling in monocytes

Cited 6 time in scopus
Metadata Downloads
Title
Effusanin C inhibits inflammatory responses via blocking NF-kB and MAPK signaling in monocytes
Author(s)
J Y Kim; H S Kim; Y J Kim; H K Lee; J S Kim; Jong Soon Kang; J T Hong; Y Kim; B Y Hwang; S B Han
Bibliographic Citation
International Immunopharmacology, vol. 15, no. 1, pp. 84-88
Publication Year
2013
Abstract
Effusanin C, a constituent of Isodon japonicus, has been used in oriental countries as a traditional folk medicine to treat inflammatory diseases, but its mechanism of action remains unknown. Here, we investigate the inhibitory activity of effusanin C in inflammatory monocytes. Effusanin C markedly inhibited the production of inflammatory mediators including nitric oxide, IL-1β, and TNF-α in macrophages and dendritic cells. Furthermore, molecular studies showed that effusanin C inhibited phosphorylation of p38, JNK, and ERK, degradation of IκBβ, and nuclear translocation of NF-κB p50/p65 in these cells. Taken together, these data show that effusanin C inhibits inflammatory responses by blocking NF-κB and MAPK signalings in monocytes.
Keyword
Dendritic cellEffusanin CMacrophageMAPKNF-κB
ISSN
1567-5769
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.intimp.2012.11.002
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.