Inhibition of TAK1 by kamebakaurin in dendritic cells

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Title
Inhibition of TAK1 by kamebakaurin in dendritic cells
Author(s)
J Y Kim; H S Kim; Y J Kim; H K Lee; J S Kim; Jong Soon Kang; J T Hong; Y Kim; B Y Hwang; S B Han
Bibliographic Citation
International Immunopharmacology, vol. 15, no. 1, pp. 138-143
Publication Year
2013
Abstract
Kamebakaurin (KA) has anti-cancer and anti-inflammatory activities through direct inhibition of DNA-binding activity of nuclear factor-kappa B (NF-κB) p50. We suggest here another molecular target of KA by the use of lipopolysaccharide-treated dendritic cells. In cell- and enzyme-based assays, KA directly inhibited autophosphorylation and kinase activity of TAK1, followed by the inhibition of TAK1-downstream signaling cascades, such as IKK phosphorylation-IκBα degradation-nuclear translocation of NF-κB, phosphorylation of MEK3/6-p38 mitogen activated protein kinase (MAPK), and MKK4/7-c-Jun N-terminal kinase MAPK. These results demonstrated that TAK1 might be the direct molecular target of KA.
Keyword
KamebakaurinMAPKNF-κBTAK1
ISSN
1567-5769
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.intimp.2012.11.004
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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