Discovery of indolyl acrylamide derivatives as human diacylglycerol acyltransferase-2 selective inhibitors

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dc.contributor.authorK Lee-
dc.contributor.authorM Kim-
dc.contributor.authorB Lee-
dc.contributor.authorJ Goo-
dc.contributor.authorJ Kim-
dc.contributor.authorR Naik-
dc.contributor.authorJee Hee Seo-
dc.contributor.authorMun-Ock Kim-
dc.contributor.authorY Byun-
dc.contributor.authorG Y Song-
dc.contributor.authorHyun Sun Lee-
dc.contributor.authorY Choi-
dc.date.accessioned2017-04-19T09:36:14Z-
dc.date.available2017-04-19T09:36:14Z-
dc.date.issued2013-
dc.identifier.issn1477-0520-
dc.identifier.uri10.1039/c2ob27114ako
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11140-
dc.description.abstractA series of indolyl acrylamide derivatives was synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Furfurylamine containing indolyl acrylamide derivative 5h exhibited the most potent DGAT inhibitory activity using microsomes prepared from rat liver. Further evaluation against human DGAT-1 and DGAT-2 identified indolyl acrylamide analogues as selective inhibitors against human DGAT-2. In addition, the most potent compound 5h inhibited triglyceride synthesis dose-dependently in HepG2 cell lines.-
dc.publisherRoyal Soc Chem-
dc.titleDiscovery of indolyl acrylamide derivatives as human diacylglycerol acyltransferase-2 selective inhibitors-
dc.title.alternativeDiscovery of indolyl acrylamide derivatives as human diacylglycerol acyltransferase-2 selective inhibitors-
dc.typeArticle-
dc.citation.titleOrganic & Biomolecular Chemistry-
dc.citation.number5-
dc.citation.endPage858-
dc.citation.startPage849-
dc.citation.volume11-
dc.contributor.affiliatedAuthorJee Hee Seo-
dc.contributor.affiliatedAuthorMun-Ock Kim-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.alternativeName이경-
dc.contributor.alternativeName김민경-
dc.contributor.alternativeName이보아-
dc.contributor.alternativeName구자일-
dc.contributor.alternativeName김지영-
dc.contributor.alternativeNameNaik-
dc.contributor.alternativeName서지희-
dc.contributor.alternativeName김문옥-
dc.contributor.alternativeName변영주-
dc.contributor.alternativeName송규용-
dc.contributor.alternativeName이현선-
dc.contributor.alternativeName최용석-
dc.identifier.bibliographicCitationOrganic & Biomolecular Chemistry, vol. 11, no. 5, pp. 849-858-
dc.identifier.doi10.1039/c2ob27114a-
dc.description.journalClassY-
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Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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