Cytotoxic petrosiacetylenes from the marine sponge Petrosia sp. = 해양 sponge Petrosia sp.에서 추출한 petrosiacetylenes의 세포 독성 효과

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Title
Cytotoxic petrosiacetylenes from the marine sponge Petrosia sp. = 해양 sponge Petrosia sp.에서 추출한 petrosiacetylenes의 세포 독성 효과
Author(s)
Y J Lee; S J Yoo; Jong Soon Kang; Ji Eun Yun; H J Shin; J S Lee; H S Lee
Bibliographic Citation
Lipids, vol. 48, no. 1, pp. 87-91
Publication Year
2013
Abstract
A novel petrosiacetylene analog (petrosiacetylene E) has been isolated from the Korean marine sponge Petrosia sp., along with petrosiacetylene A, B and C. Their structures were elucidated on the basis of spectroscopic methods and the stereochemistry of the new compound was determined by using the modified Mosher's method. Petrosiacetylene E showed higher cytotoxicity against five human cancer cell lines than petrosiacetylene A and B, presumably due to the additional hydroxy group located at C-16.
Keyword
CytotoxicityPetrosiaPetrosiacetylenePolyacetylenic alcoholSponge
ISSN
0024-4201
Publisher
Wiley
DOI
http://dx.doi.org/10.1007/s11745-012-3727-5
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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