The production of 1,3-propanediol from mixtures of glycerol and glucose by a Klebsiella pneumoniae mutant deficient in carbon catabolite repression

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Title
The production of 1,3-propanediol from mixtures of glycerol and glucose by a Klebsiella pneumoniae mutant deficient in carbon catabolite repression
Author(s)
Baek Rock Oh; Won-Kyung Hong; Sun-Yeon Heo; L H Luo; A Kondo; Jeong-Woo SeoChul Ho Kim
Bibliographic Citation
Bioresource Technology, vol. 130, pp. 719-724
Publication Year
2013
Abstract
In the present study, mutant strain of Klebsiella pneumoniae with deletion of the crr gene encoding EIIAGlc (a component of the glucose-specific phosphoenolpyruvate-dependent transferase system [PTS]) was prepared. This eliminated the ability of the strain to mediate carbon catabolite repression (CCR). Production of 1,3-propanediol (1,3-PD) from glycerol by the crr mutant strain was enhanced (compared to that of the parent) in the presence of glucose. Using molasses as a co-substrate of glycerol, the maximum yield of 1,3-PD was 60.4% greater (81.2g/l) than that obtained when glycerol was used alone, under optimum fermentation conditions.
Keyword
1,3-PropanediolCarbon catabolite repressionCrrKlebsiella pneumoniaeMixtures of glycerol and glucose
ISSN
0960-8524
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.biortech.2012.12.076
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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