DC Field | Value | Language |
---|---|---|
dc.contributor.author | Joohyun Ryu | - |
dc.contributor.author | Sung Goo Park | - |
dc.contributor.author | Phil Young Lee | - |
dc.contributor.author | S Cho | - |
dc.contributor.author | D H Lee | - |
dc.contributor.author | G H Kim | - |
dc.contributor.author | Jeong Hoon Kim | - |
dc.contributor.author | Byoung Chul Park | - |
dc.date.accessioned | 2017-04-19T09:36:42Z | - |
dc.date.available | 2017-04-19T09:36:42Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | 10.1016/j.bbrc.2012.11.105 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11173 | - |
dc.description.abstract | Anterior Gradient 2 (AGR2), an ER stress-inducible protein, has been reported to be localized in endoplasmic reticulum (ER) and its level is elevated in numerous metastatic cancers. Recently, it has been demonstrated that AGR2 is involved in the control of ER homeostasis. However, the molecular mechanism how AGR2 regulates ER stress response remains unclear. Herein we show that AGR2 homo-dimerizes through an intermolecular disulfide bond. Moreover, dimerization of AGR2 attenuates ER stress-induced cell death through the association with BiP/GRP78. Thus, these results suggest that dimerization of AGR2 is crucial in mediating the ER stress signaling pathway. | - |
dc.publisher | Elsevier | - |
dc.title | Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78 | - |
dc.title.alternative | Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78 | - |
dc.type | Article | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 615 | - |
dc.citation.startPage | 610 | - |
dc.citation.volume | 430 | - |
dc.contributor.affiliatedAuthor | Joohyun Ryu | - |
dc.contributor.affiliatedAuthor | Sung Goo Park | - |
dc.contributor.affiliatedAuthor | Phil Young Lee | - |
dc.contributor.affiliatedAuthor | Jeong Hoon Kim | - |
dc.contributor.affiliatedAuthor | Byoung Chul Park | - |
dc.contributor.alternativeName | 유주현 | - |
dc.contributor.alternativeName | 박성구 | - |
dc.contributor.alternativeName | 이필영 | - |
dc.contributor.alternativeName | 조사연 | - |
dc.contributor.alternativeName | 이도희 | - |
dc.contributor.alternativeName | 김광훈 | - |
dc.contributor.alternativeName | 김정훈 | - |
dc.contributor.alternativeName | 박병철 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, vol. 430, no. 2, pp. 610-615 | - |
dc.identifier.doi | 10.1016/j.bbrc.2012.11.105 | - |
dc.subject.keyword | AGR2 | - |
dc.subject.keyword | Dimerization | - |
dc.subject.keyword | ER stress | - |
dc.subject.keyword | UPR signaling pathway | - |
dc.subject.local | AGR2 | - |
dc.subject.local | Dimerization | - |
dc.subject.local | ER stress | - |
dc.subject.local | UPR signaling pathway | - |
dc.description.journalClass | Y | - |
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