Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78

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dc.contributor.authorJoohyun Ryu-
dc.contributor.authorSung Goo Park-
dc.contributor.authorPhil Young Lee-
dc.contributor.authorS Cho-
dc.contributor.authorD H Lee-
dc.contributor.authorG H Kim-
dc.contributor.authorJeong Hoon Kim-
dc.contributor.authorByoung Chul Park-
dc.date.accessioned2017-04-19T09:36:42Z-
dc.date.available2017-04-19T09:36:42Z-
dc.date.issued2013-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2012.11.105ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11173-
dc.description.abstractAnterior Gradient 2 (AGR2), an ER stress-inducible protein, has been reported to be localized in endoplasmic reticulum (ER) and its level is elevated in numerous metastatic cancers. Recently, it has been demonstrated that AGR2 is involved in the control of ER homeostasis. However, the molecular mechanism how AGR2 regulates ER stress response remains unclear. Herein we show that AGR2 homo-dimerizes through an intermolecular disulfide bond. Moreover, dimerization of AGR2 attenuates ER stress-induced cell death through the association with BiP/GRP78. Thus, these results suggest that dimerization of AGR2 is crucial in mediating the ER stress signaling pathway.-
dc.publisherElsevier-
dc.titleDimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78-
dc.title.alternativeDimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number2-
dc.citation.endPage615-
dc.citation.startPage610-
dc.citation.volume430-
dc.contributor.affiliatedAuthorJoohyun Ryu-
dc.contributor.affiliatedAuthorSung Goo Park-
dc.contributor.affiliatedAuthorPhil Young Lee-
dc.contributor.affiliatedAuthorJeong Hoon Kim-
dc.contributor.affiliatedAuthorByoung Chul Park-
dc.contributor.alternativeName유주현-
dc.contributor.alternativeName박성구-
dc.contributor.alternativeName이필영-
dc.contributor.alternativeName조사연-
dc.contributor.alternativeName이도희-
dc.contributor.alternativeName김광훈-
dc.contributor.alternativeName김정훈-
dc.contributor.alternativeName박병철-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 430, no. 2, pp. 610-615-
dc.identifier.doi10.1016/j.bbrc.2012.11.105-
dc.subject.keywordAGR2-
dc.subject.keywordDimerization-
dc.subject.keywordER stress-
dc.subject.keywordUPR signaling pathway-
dc.subject.localAGR2-
dc.subject.localDimerization-
dc.subject.localER stress-
dc.subject.localUPR signaling pathway-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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