Effect of Vigna angularis ethanol extract on papain-induced arthritis in mice = 팥 에탄올 추출물의 Papain 유도 관절염 마우스에서의 항 골관절염 효과

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Title
Effect of Vigna angularis ethanol extract on papain-induced arthritis in mice = 팥 에탄올 추출물의 Papain 유도 관절염 마우스에서의 항 골관절염 효과
Author(s)
S H Jeoung; S H Kim; H K Kim; B R Yun; H W Lee; J H Lim; Mun Chual Rho; D H Kim
Bibliographic Citation
Korean Journal of Oriental Physiology & Pathology, vol. 26, no. 5, pp. 665-671
Publication Year
2012
Abstract
C57BL/10 mice. The C57BL/10 mice were injected with papain and oral administration of Vigna angularis ethanol extract (VA-E) at different doses (100 and 200 mg/kg) once a day for 42 days and compared with untreated mice. Histological examination and the measurement of inflammatory cytokine release were performed. The results showed that comparing with untreated mice, the treatment with Vigna angularis ethanol extract (VA-E) decreased the pathological changes of knee joint tissue. The level of inflammatory cytokine secreted from the tissues, such as IL-1β (interleukin-1β), IL-6 (interleukin-6), TNF-α (Tumor Necrosis Factor-α), were decreased. These results were confirmed by the quantification of cartilage volume using micro CT scanning. Consequently, Vigna angularis ethanol extract (VA-E) has a therapeutic potential in inflammatory joint diseases such as osteoarthritis.
Keyword
vigna angularisosteoarthritiscytokinescartilage volume
ISSN
1738-7698
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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