Ethanol extract of Alismatis Rhizoma reduces acute lung inflammation by suppressing NF-kB and activating Nrf2 = 알리스마트 리조마의 급성폐염증 억제효과

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dc.contributor.authorC W Han-
dc.contributor.authorM J Kwun-
dc.contributor.authorK H Kim-
dc.contributor.authorJ Y Choi-
dc.contributor.authorSei Ryang Oh-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorJ H Lee-
dc.contributor.authorM Joo-
dc.date.accessioned2017-04-19T09:36:56Z-
dc.date.available2017-04-19T09:36:56Z-
dc.date.issued2013-
dc.identifier.issn0378-8741-
dc.identifier.uri10.1016/j.jep.2013.01.010ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11213-
dc.description.abstractEthnopharmacological relevance: The tuber of Alisma orientale Juzepzuk, a medicinal herb that has been used for the treatment of various disorders in Korea, has an anti-inflammatory effect. Here, we investigated a possible underlying mechanism and a protective effect on acute lung injury (ALI). Materials and methods: Alisma orientale tuber was extracted in 80% ethanol and dried. The powder of the ethanol extract of Alisma orientale tuber (EEAO) was dissolved in PBS. The effect of EEAO on NF-κB and Nrf2 activities was analyzed with RAW 264.7 cells. The effect of EEAO on lung inflammation was determined by histologic and molecular biological analyses of the lung tissue of C57BL/6 mice that were gavaged once a day with 0.3 or 1.2 g/kg of EEAO for 14 days, prior to an intranasal administration of LPS (0.01 g/kg) for inducing ALI. Results: EEAO pre-treatment of RAW 264.7 cells suppressed NF-κB activity and the expression of its dependent genes including COX-2, IL-1β and iNOS. Similar treatment enhanced Nrf2 activity and the expression of Nrf2-regulated genes including NQO-1, HO-1 and GCLC. LPS instillation induced acute neutrophilic lung inflammation, which was significantly suppressed by pre-treatment with EEAO. Analysis of the lungs revealed that EEAO pre-treatment induced the expression of Nrf2-regulated genes, with concomitant down-regulation of inflammatory gene expression. Conclusions: EEAO attenuated lung inflammation in LPS-induced ALI mice, which was associated with differential regulation of NF-κB and Nrf2 activities. We suggest that EEAO can be developed as a potential therapeutics for the treatment of ALI.-
dc.publisherElsevier-
dc.titleEthanol extract of Alismatis Rhizoma reduces acute lung inflammation by suppressing NF-kB and activating Nrf2 = 알리스마트 리조마의 급성폐염증 억제효과-
dc.title.alternativeEthanol extract of Alismatis Rhizoma reduces acute lung inflammation by suppressing NF-kB and activating Nrf2-
dc.typeArticle-
dc.citation.titleJournal of Ethnopharmacology-
dc.citation.number1-
dc.citation.endPage410-
dc.citation.startPage402-
dc.citation.volume146-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.alternativeName한창우-
dc.contributor.alternativeName권민정-
dc.contributor.alternativeName김균하-
dc.contributor.alternativeName최준용-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName이장훈-
dc.contributor.alternativeName주명수-
dc.identifier.bibliographicCitationJournal of Ethnopharmacology, vol. 146, no. 1, pp. 402-410-
dc.identifier.doi10.1016/j.jep.2013.01.010-
dc.subject.keywordAcute lung injury-
dc.subject.keywordAlisma orientale-
dc.subject.keywordAnti-inflammation-
dc.subject.keywordNF-κB-
dc.subject.keywordNrf2-
dc.subject.localAcute lung injury-
dc.subject.localacute lung injury-
dc.subject.localAcute Lung Injury-
dc.subject.localacute lung injury (ALI)-
dc.subject.localAlisma orientale-
dc.subject.localantiinflammation-
dc.subject.localAntiinflammation-
dc.subject.localanti-inflammation-
dc.subject.localAnti-Inflammation-
dc.subject.localAnti-inflammation-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.subject.localNRF2-
dc.subject.localNrf2-
dc.subject.localNrf-2-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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