Prolonged shedding of the canine influenza H3N2 virus in nasal swabs of experimentally immunocompromised dogs

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dc.contributor.authorMinki Hong-
dc.contributor.authorB Kang-
dc.contributor.authorWoonsung Na-
dc.contributor.authorD An-
dc.contributor.authorH Moon-
dc.contributor.authorDoo Jin Kim-
dc.contributor.authorJ Oh-
dc.contributor.authorSeong-Jun Park-
dc.contributor.authorHaryoung Poo-
dc.contributor.authorJ K Kim-
dc.contributor.authorJ Kim-
dc.contributor.authorDae Sub Song-
dc.date.accessioned2017-04-19T09:37:01Z-
dc.date.available2017-04-19T09:37:01Z-
dc.date.issued2013-
dc.identifier.issn2287-3651-
dc.identifier.uri10.7774/cevr.2013.2.1.66ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11232-
dc.description.abstractPurpose: The avian origin canine influenza virus H3N2 has been recently isolated and found to be currently in dog population in South Korea and China. The purpose of this study was to clarify the relationship between immunosuppressive glucocorticoids used in veterinary clinical practice and viral shedding pattern of influenza in dogs. Materials and Methods: Eight conventional beagle dogs were divided into control infection group and immunocompromised group. Dogs of both groups were infected with H3N2 canine influenza virus (2×106.0 EID50/0.1 mL). Dogs in immunocompromised group were given orally 3.0 mg/kg prednisolone for 7 days. Virus shedding was monitored using real-time polymerase chain reaction. After necropsy, histopathologic lesions were compared. Results: We found that immunocompromised dogs exhibited more prolonged (8 days vs. 13 days) and higher magnitude viral shedding than control group (peak titer of viral shedding 4.6 vs. 5.5 EID50). Conclusion: Restricted use of immunosuppressive drugs in the clinical setting might help control the rapid spread of H3N2 through local dog populations.-
dc.publisherKorean Vaccine Societyko
dc.titleProlonged shedding of the canine influenza H3N2 virus in nasal swabs of experimentally immunocompromised dogs-
dc.title.alternativeProlonged shedding of the canine influenza H3N2 virus in nasal swabs of experimentally immunocompromised dogs-
dc.typeArticle-
dc.citation.titleClinical and Experimental Vaccine Research-
dc.citation.number1-
dc.citation.endPage68-
dc.citation.startPage66-
dc.citation.volume2-
dc.contributor.affiliatedAuthorMinki Hong-
dc.contributor.affiliatedAuthorWoonsung Na-
dc.contributor.affiliatedAuthorDoo Jin Kim-
dc.contributor.affiliatedAuthorSeong-Jun Park-
dc.contributor.affiliatedAuthorHaryoung Poo-
dc.contributor.affiliatedAuthorDae Sub Song-
dc.contributor.alternativeName홍민기-
dc.contributor.alternativeName강보규-
dc.contributor.alternativeName나운성-
dc.contributor.alternativeName안동준-
dc.contributor.alternativeName문형준-
dc.contributor.alternativeName김두진-
dc.contributor.alternativeName오진식-
dc.contributor.alternativeName박성준-
dc.contributor.alternativeName부하령-
dc.contributor.alternativeName김정기-
dc.contributor.alternativeName김종만-
dc.contributor.alternativeName송대섭-
dc.identifier.bibliographicCitationClinical and Experimental Vaccine Research, vol. 2, no. 1, pp. 66-68-
dc.identifier.doi10.7774/cevr.2013.2.1.66-
dc.subject.keywordCanine influenza virus-
dc.subject.keywordGlucocorticoid-
dc.subject.keywordImmunosuppression-
dc.subject.keywordViral load-
dc.subject.localcanine influenza virus-
dc.subject.localCanine influenza virus-
dc.subject.localGlucocorticoid-
dc.subject.localImmunosuppression-
dc.subject.localimmunosuppression-
dc.subject.localViral loads-
dc.subject.localViral load-
dc.description.journalClassN-
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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