Natural flavone Jasceosidin is a neuroinflammation inhibitor = Jaceosidin의 신경세포 염증 저해 효과

Cited 28 time in scopus
Metadata Downloads
Title
Natural flavone Jasceosidin is a neuroinflammation inhibitor = Jaceosidin의 신경세포 염증 저해 효과
Author(s)
Y Nam; M Choi; H Hwang; M G Lee; Byoung-Mog Kwon; W H Lee; K Suk
Bibliographic Citation
Phytotherapy Research, vol. 27, no. 5, pp. 404-411
Publication Year
2013
Abstract
Jaceosidin is a naturally occurring flavone with pharmacological activity. Jaceosidin, as one of the major constituents of the medicinal herbs of the genus Artemisia, has been shown to exert anticancer, anti-oxidative, anti-inflammatory, and immunosuppressive effects. This study was undertaken to determine the effect of jaceosidin on microglia and neuroinflammation. Microglia are the innate immune cells in the central nervous system, and they play a central role in the initiation and maintenance of neuroinflammation. We report that jaceosidin inhibits inflammatory activation of microglia, reducing nitric oxide (NO) production and proinflammatory cytokine expression. IC50 for NO inhibition was 27 ± 0.4 μM. The flavone also attenuated microglial neurotoxicity in the microglia/neuroblastoma co-culture. Systemic injection of jaceosidin ameliorated neuroinflammation in the mouse model of experimental allergic encephalomyelitis. These results indicate that plant flavone jaceosidin is a microglial inhibitor with anti-neuroinflammation activity.
Keyword
jaceosidinmicroglianeuroinflammationflavonenitric oxide.
ISSN
0951-418X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/ptr.4737
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.