Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells

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Title
Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells
Author(s)
S W Oh; J B Lee; B Kim; S Jeon; M K Kim; Ki Hoan Nam; J R Ha; M Bhatia; G T Oh; D Y Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 35, no. 11, pp. 1979-1988
Publication Year
2012
Abstract
Embryonic stem (ES) cells may be used as an alternative source of functionally intact cardiomyocytes for ischemic heart disease. Several natural and synthetic small molecules have been identified as useful tools for controlling and manipulating stem cell renewal and differentiation. Currently, there is an urgent requirement for novel small molecules that specifically induce differentiation of stem cells into cardiomyocytes. To identify compounds that promote cardiomyogenesis of stem cells, cell-based screening of a peptidomimetic small-molecule library was carried out. A series of β-turn peptidomimetic compounds, including CW209E, increased the expression of α-MHC promoter-driven enhanced green fluorescent protein (EGFP) and ratio of beating embryoid bodies (EBs) without inducing cytotoxicity in mouse embryonic stem cells. CW209E also increased the number of beating EBs in human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Thus, this chemical compound should be useful for elucidation of the molecular pathway of cardiogenesis and generation of cardiomyocytes ex vivo, which can be further applied for experimental or clinical cell therapy for ischemic heart diseases.
Keyword
CardiogenesisEmbryonic stem cellsIschemic heart diseasePeptidomimetic compounds
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-012-1115-6
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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