Protective effect of silymarin against ethanol-induced gastritis in rats: Role of sulfhydryls, nitric oxide and gastric sensory afferents

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dc.contributor.authorJung Hyu Shin-
dc.contributor.authorChang Woo Lee-
dc.contributor.authorSoo Jin Oh-
dc.contributor.authorJi Eun Yun-
dc.contributor.authorK Lee-
dc.contributor.authorS K Park-
dc.contributor.authorH M Kim-
dc.contributor.authorS B Han-
dc.contributor.authorY Kim-
dc.contributor.authorHyoung-Chin Kim-
dc.contributor.authorJong Soon Kang-
dc.date.accessioned2017-04-19T09:37:24Z-
dc.date.available2017-04-19T09:37:24Z-
dc.date.issued2013-
dc.identifier.issn0278-6915-
dc.identifier.uri10.1016/j.fct.2013.01.019ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11249-
dc.description.abstractSilymarin has been known to exert antioxidant, anti-carcinogenic and anti-inflammatory effects. In this study, we examined the effect of silymarin on gastritis in rats. Oral administration of silymarin dose-dependently decreased gastric lesions in ethanol-induced gastritis model. Silymarin also significantly suppressed the development of gastric lesions in aspirin- or water immersion-restraint stress-induced gastritis models. Further study demonstrated that the gastroprotective effect of silymarin was blocked by nitric oxide (NO) synthase inhibitor l-NAME, SH blocker N-ethylmaleimide or TRPV1 antagonist capsazepine in ethanol-induced gastritis model. In addition, ex vivo analysis revealed that ethanol-induced decrease in gastric mucus and non-protein sulfhydryl (NPSH) groups was significantly reversed by silymarin treatment and lipid peroxidation was also suppressed by silymarin in ethanol-induced gastritis model. Taken together, these results suggest that silymarin exerts gastroprotective effects and the gastroprotective effects of silymarin might be related to the protection of gastric mucosal NO and NP-SH and the modulation of capsaicin-sensitive gastric sensory afferents.-
dc.publisherElsevier-
dc.titleProtective effect of silymarin against ethanol-induced gastritis in rats: Role of sulfhydryls, nitric oxide and gastric sensory afferents-
dc.title.alternativeProtective effect of silymarin against ethanol-induced gastritis in rats: Role of sulfhydryls, nitric oxide and gastric sensory afferents-
dc.typeArticle-
dc.citation.titleFood and Chemical Toxicology-
dc.citation.number0-
dc.citation.endPage357-
dc.citation.startPage353-
dc.citation.volume55-
dc.contributor.affiliatedAuthorJung Hyu Shin-
dc.contributor.affiliatedAuthorChang Woo Lee-
dc.contributor.affiliatedAuthorSoo Jin Oh-
dc.contributor.affiliatedAuthorJi Eun Yun-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeName신정휴-
dc.contributor.alternativeName이창우-
dc.contributor.alternativeName오수진-
dc.contributor.alternativeName윤지은-
dc.contributor.alternativeName이기호-
dc.contributor.alternativeName박성규-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName한상배-
dc.contributor.alternativeName김영수-
dc.contributor.alternativeName김형진-
dc.contributor.alternativeName강종순-
dc.identifier.bibliographicCitationFood and Chemical Toxicology, vol. 55, pp. 353-357-
dc.identifier.doi10.1016/j.fct.2013.01.019-
dc.subject.keywordGastric sensory afferents-
dc.subject.keywordGastritis-
dc.subject.keywordNitric oxide-
dc.subject.keywordNon-protein sulfhydryl-
dc.subject.keywordSilymarin-
dc.subject.localGastric sensory afferents-
dc.subject.localgastritis-
dc.subject.localGastritis-
dc.subject.localNO-
dc.subject.localnitric oxide-
dc.subject.localnitric oxide (NO)-
dc.subject.localNitric oxide-
dc.subject.localNO (Nitric oxide)-
dc.subject.localnitric oxide.-
dc.subject.localNitric oxid-
dc.subject.localNitric oxide (NO)-
dc.subject.localNon-protein sulfhydryl-
dc.subject.localsilymarin-
dc.subject.localSilymarin-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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